Substantive Dimethicone-Based Mucoadhesive Coatings.

Sophie Miller, Nicole Omoto, Ryan DeCamp, Gavin Gloeb, Stephen M Gross

Abstract read

In one paragraph

Article in Materials (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Sophie MillerDepartment of Chemistry, College of Arts and Sciences, Creighton University, Omaha, NE 68178, USA.

Nicole OmotoDepartment of Oral Biology, School of Dentistry, Creighton University, Omaha, NE 68178, USA.

Ryan DeCampDepartment of Chemistry, College of Arts and Sciences, Creighton University, Omaha, NE 68178, USA.

Gavin GloebDepartment of Chemistry, College of Arts and Sciences, Creighton University, Omaha, NE 68178, USA.

Stephen M GrossDepartment of Chemistry, College of Arts and Sciences, Creighton University, Omaha, NE 68178, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

It is challenging to deliver therapeutics in the oral environment due to the wet surfaces, the nature of the mucosa and the potential for saliva washout. In this study, the development of a mucoadhesive dimethicone-based oral carrier system for adhesion to the hard tissue and mucosa in the mouth was examined. This study reports the viscosity and mucoadhesion of dimethicone based polymer blends. The viscosity of the materials was measured using a rheometer. The mucoadhesion of these materials was determined as the work of adhesion and peak tack force using the tensile test method with a texture analyzer. Materials were prepared with either calcium and phosphate salts or sodium fluoride as potential therapeutics for promoting remineralization and treating dentin hypersensitivity by mechanical occlusion. Scanning electron microscopy was used to look at mineral deposition on the surface of dental hard tissue after the application of the dimethicone-based formulations. The results of this study confirm the potential for using these dimethicone-based materials as mucoadhesive therapeutic delivery systems in the oral environment.

Indexed as

dimethiconefluoridehypersensitivitymucoadhesion

Identifiers

PMID39597413

DOI10.3390/ma17225590

PMCPMC11595981

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LicenceCC BY

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.