Evidence map›Paper›PMID 39596994›Full record

ReviewMedicina (Kaunas, Lithuania)2024

The Potential Role of the Microbiome in the Pathogenesis of Nasal Tumors: A Comprehensive Review.

Antonella Loperfido, Davide Rizzo, Bruno Fionda, Luca Mureddu, Andrea Tondo, Luca Tagliaferri, Gianluca Bellocchi, Giovanni Delogu, Francesco Bussu

Abstract readReview
In one paragraph

Review in Medicina (Kaunas, Lithuania), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Observational
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Antonella LoperfidoOtolaryngology Unit, San Camillo Forlanini Hospital, 00152 Rome, Italy.ORCID 0000-0002-7174-8126
Davide RizzoOtolaryngology Division, Azienda Ospedaliera Universitaria di Sassari, 07100 Sassari, Italy.ORCID 0000-0003-1830-3731
Bruno FiondaUOC Degenze di Radioterapia Oncologica, Dipartimento di Diagnostica per Immagini e Radioterapia Oncologica, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy.ORCID 0000-0003-3368-1810
Luca MuredduOtolaryngology Division, Azienda Ospedaliera Universitaria di Sassari, 07100 Sassari, Italy.ORCID 0000-0002-2598-198X
Andrea TondoOtolaryngology Division, Azienda Ospedaliera Universitaria di Sassari, 07100 Sassari, Italy.ORCID 0009-0001-4952-2729
Luca TagliaferriUOC Degenze di Radioterapia Oncologica, Dipartimento di Diagnostica per Immagini e Radioterapia Oncologica, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy.ORCID 0000-0003-2308-0982
Gianluca BellocchiOtolaryngology Unit, San Camillo Forlanini Hospital, 00152 Rome, Italy.
Giovanni DeloguDipartimento di Scienze Biotecnologiche di Base, Cliniche Intensivologiche e Perioperatorie-Sezione di Microbiologia, Università Cattolica del Sacro Cuore, 00168 Rome, Italy.
Francesco BussuOtolaryngology Division, Azienda Ospedaliera Universitaria di Sassari, 07100 Sassari, Italy.ORCID 0000-0001-6261-2772

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cancers of the nose, and especially the nose vestibule, represent a significant challenge for clinicians due to their rarity, the intricate nature of surrounding vital structures, the nonspecific early symptoms, and the etiological factors that are not completely understood. Emerging research suggests that alterations in the nasal microbiome, also known as microbial dysbiosis, may contribute to the pathogenesis of those malignancies through mechanisms involving chronic inflammation, immune modulation, and cellular changes. The aims of this paper are to review the current literature covering the nasal microbiome's role in carcinogenesis, particularly in the context of squamous cell carcinoma, and to explore how microbial dysbiosis might foster a pro-tumorigenic environment. It further discusses potential future directions for research and therapeutic approaches.

Indexed as

MicrobiotaNose NeoplasmsCarcinogenesisCarcinoma, Squamous CellDysbiosisHumanscarcinogenesisdysbiosisHPVHuman Papilloma Virusmicrobiomenasal tumorsnasal vestibuleparanasal sinusesSCCsquamous cell carcinoma

Identifiers

PMID39596994
PMCPMC11596812

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.