Evidence map›Paper›PMID 39596796›Full record

ArticleAntibiotics (Basel, Switzerland)2024

Model-Based Dose Identification of Dalbavancin for Long-Term Suppressive Outpatient Treatment of Ventricular Assist Device Infections.

Ute Chiriac, Uwe Liebchen, Otto Roman Frey, Heike Lanzinger, Sabrina Klein, Torsten Hoppe-Tichy, Matthias Karck, Anna Meyer, Benedict Morath

Abstract read
In one paragraph

Article in Antibiotics (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ute ChiriacHospital Pharmacy, Heidelberg University Hospital, Im Neuenheimer Feld 670, 69120 Heidelberg, Germany.ORCID 0000-0002-4288-1745
Uwe LiebchenDepartment of Anaesthesiology, University Hospital, Ludwig Maximilians University of Munich, Marchioninistraße 15, 81377 Munich, Germany.ORCID 0000-0002-4375-0923
Otto Roman FreyHospital Pharmacy, General Hospital Heidenheim, Schlosshausstrasse 100, 89522 Heidenheim, Germany.ORCID 0000-0001-9482-5094
Heike LanzingerHospital Pharmacy, General Hospital Heidenheim, Schlosshausstrasse 100, 89522 Heidenheim, Germany.
Sabrina KleinDepartment of Infectious Diseases, Medical Microbiology and Hygiene, Medical Faculty Heidelberg, Heidelberg University, Im Neuenheimer Feld 324, 69120 Heidelberg, Germany.ORCID 0000-0003-0645-3740
Torsten Hoppe-TichyHospital Pharmacy, Heidelberg University Hospital, Im Neuenheimer Feld 670, 69120 Heidelberg, Germany.
Matthias KarckDepartment of Cardiac Surgery, Heidelberg University Hospital, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany.
Anna MeyerDepartment of Cardiac Surgery, Heidelberg University Hospital, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany.ORCID 0000-0002-4833-8014
Benedict MorathHospital Pharmacy, Heidelberg University Hospital, Im Neuenheimer Feld 670, 69120 Heidelberg, Germany.ORCID 0000-0003-1926-0585

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Increasing evidence suggests that dalbavancin is an effective long-term treatment for ventricular assist device (VAD) infections, with various prolonged dosing regimens currently in use. This retrospective study aimed to assess dalbavancin pharmacokinetics in VAD patients and identify optimal, feasible dosing regimens for long-term suppressive outpatient therapy. Data from Heidelberg University Hospital's VAD register were analyzed using non-linear mixed-effects modeling for pharmacokinetic analysis and dosing simulations (Lixoft

Indexed as

dalbavancinlong-term treatmentpopulation pharmacokineticstherapeutic drug monitoringventricular assist device

Identifiers

PMID39596796
PMCPMC11591545

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.