Evidence map›Paper›PMID 39596764›Full record

ReviewAntibiotics (Basel, Switzerland)2024

Biochemistry and Future Perspectives of Antibiotic Resistance: An Eye on Active Natural Products.

Giulia Caioni, Carolina Pérez Reyes, Davide Laurenti, Carmen Chiaradia, Enrico Dainese, Roberto Mattioli, Daniel Di Risola, Eleonora Santavicca, Antonio Francioso

Abstract readReview
In one paragraph

Review in Antibiotics (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Review
  3. Biosurfactant Produced byMicroorganisms · 2025
    Article
  4. Review
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Giulia CaioniDepartment of Bioscience and Technology for Food Agriculture and Environment, University of Teramo, 64100 Teramo, Italy.
Carolina Pérez ReyesDepartment of Biochemistry, Microbiology, Cell Biology and Genetics, Instituto Universitario de Bio-Orgánica "Antonio González", University of La Laguna, 38206 San Cristobal de La Laguna, Spain.ORCID 0000-0002-2117-8794
Davide LaurentiDepartment of Biochemical Sciences "A. Rossi Fanelli", Sapienza University of Rome, 00185 Rome, Italy.
Carmen ChiaradiaDepartment of Biochemical Sciences "A. Rossi Fanelli", Sapienza University of Rome, 00185 Rome, Italy.
Enrico DaineseDepartment of Bioscience and Technology for Food Agriculture and Environment, University of Teramo, 64100 Teramo, Italy.ORCID 0000-0001-7163-9344
Roberto MattioliDepartment of Biochemical Sciences "A. Rossi Fanelli", Sapienza University of Rome, 00185 Rome, Italy.ORCID 0000-0002-4452-9753
Daniel Di RisolaDepartment of Biochemical Sciences "A. Rossi Fanelli", Sapienza University of Rome, 00185 Rome, Italy.ORCID 0000-0001-6441-5668
Eleonora SantaviccaFarmacia D'Onofrio, San Pio delle Camere, 67020 L'Aquila, Italy.
Antonio FranciosoDepartment of Bioscience and Technology for Food Agriculture and Environment, University of Teramo, 64100 Teramo, Italy.ORCID 0000-0001-9822-0260

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antibiotic resistance poses a serious threat to the current healthcare system, negatively impacting the effectiveness of many antimicrobial treatments. The situation is exacerbated by the widespread overuse and abuse of available antibiotics, accelerating the evolution of resistance. Thus, there is an urgent need for novel approaches to therapy to overcome established resistance mechanisms. Plants produce molecules capable of inhibiting bacterial growth in various ways, offering promising paths for the development of alternative antibiotic medicine. This review emphasizes the necessity of research efforts on plant-derived chemicals in the hopes of finding and creating novel drugs that can successfully target resistant bacterial populations. Investigating these natural chemicals allows us to improve our knowledge of novel antimicrobial pathways and also expands our antibacterial repertoire with novel molecules. Simultaneously, it is still necessary to utilize present antibiotics sparingly; prudent prescribing practices must be encouraged to extend the effectiveness of current medications. The combination of innovative drug research and responsible drug usage offers an integrated strategy for managing the antibiotic resistance challenge.

Indexed as

antibiotic resistanceantibioticsbiological chemistrynatural bioactive compoundsone healthpharmacologyphytochemistryplants

Identifiers

PMID39596764
PMCPMC11591525

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.