Evidence map›Paper›PMID 39596595›Full record

ArticleGenes2024

Intergenic Interactions of ESR1, GSTO1 and AGER and Risk of Dementia in Community-Dwelling Elderly (SADEM Study).

Teresa Juárez-Cedillo, Nancy Martínez-Rodríguez, Enrique Juárez-Cedillo, Alfredo Ramirez, Alan Suerna-Hernández

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Teresa Juárez-CedilloUnidad de Investigación Médica en Epidemiológica Clínica, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City 06720, CP, Mexico.
Nancy Martínez-RodríguezEpidemiology, Endocrinology and Nutrition Research Unit, Hospital Infantil de México Federico Gómez, Ministry of Health (SSA), Mexico City 06720, CP, Mexico.ORCID 0000-0002-7840-983X
Enrique Juárez-CedilloFacultad de Medicina, Universidad Nacional Autónoma de Mexico, Mexico City 04360, CP, Mexico.
Alfredo RamirezDivision of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, University of Cologne, 50923 Köln, Germany.
Alan Suerna-HernándezFacultad de Medicina, Universidad Nacional Autónoma de Mexico, Mexico City 04360, CP, Mexico.

Funding

Consejo Nacional de Humanidades, Ciencias y Tecnologías SALUD- 233065
6 · The paper itself

Abstract

backgroundDementia causes the loss of functional independence, resulting in a decrease in the quality of life of those who suffer from it.

aimsThis study aimed to investigate the interactions influencing susceptibility to the development of dementia through multifactor dimensionality reduction (MDR).

methodsthe study population was made up of 221 cases and 534 controls. We performed an MDR analysis as well as a bioinformatic analysis to identify interactions between the genes

resultsWe observed associations between the polymorphism of GSTO1 and risk of dementia for the site rs4925 with the recessive model (OR = 1.720, 95% CI = 1.166-2.537

conclusionsThe MDR and bioinformatics results provide new information on the molecular pathogenesis of dementia, allowing identification of possible diagnostic markers and new therapeutic targets.

Indexed as

DementiaEstrogen Receptor alphaGenetic Predisposition to DiseasePolymorphism, Single NucleotideAgedAged, 80 and overCase-Control StudiesFemaleGlutathione TransferaseHumansIndependent LivingMaleRisk FactorsESR1 protein, humanEstrogen Receptor alphaGlutathione TransferaseGSTO1 protein, humanAGERbioinformaticdementiaESR1gen-gen interactionGSTO1MDRpolymorphism

Identifiers

PMID39596595
PMCPMC11594218

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.