Evidence map›Paper›PMID 39596587›Full record

ArticleGenes2024

Gene Variant Frequencies of

Lindsey Contella, Christopher L Farrell, Luigi Boccuto, Alain Litwin, Marion L Snyder

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Lindsey ContellaHealthcare Genetics and Genomics, School of Nursing, Clemson University, 605 Grove Rd., Greenville, SC 29605, USA.ORCID 0009-0004-8549-5299
Christopher L FarrellHealthcare Genetics and Genomics, School of Nursing, Clemson University, 605 Grove Rd., Greenville, SC 29605, USA.ORCID 0000-0002-3672-3492
Luigi BoccutoHealthcare Genetics and Genomics, School of Nursing, Clemson University, 605 Grove Rd., Greenville, SC 29605, USA.ORCID 0000-0003-2017-4270
Alain LitwinSchool of Health Research, Clemson University, Clemson, SC 29631, USA.
Marion L SnyderLuxor Scientific, LLC, 1327 Miller Rd., Greenville, SC 29607, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSubstance use disorder in the United States represents a complex and growing public health crisis, marked by increasing rates of overdose deaths and the misuse of prescription medications. There is a critical need for furthering the understanding of the molecular and genetic mechanisms that can lead to substance use disorder. Identifying significant variants in the kynurenine pathway could help identify therapeutic targets for intervention.

methodsThe All of Us cohort builder evaluated the frequency of variants of four genes,

resultsChi-square analysis showed a significant variation in genetic frequency (

conclusionsThis study found associations of polymorphisms in the

Indexed as

Indoleamine-Pyrrole 2,3,-DioxygenaseSubstance-Related DisordersTryptophan OxygenaseAdultCohort StudiesFemaleGene FrequencyGenetic Predisposition to DiseaseHumansKynurenineKynurenine 3-MonooxygenaseMalePolymorphism, Single NucleotideIDO1 protein, humanIDO2 protein, humanIndoleamine-Pyrrole 2,3,-DioxygenaseKynurenineKynurenine 3-MonooxygenaseTryptophan Oxygenasegenetic frequencykynurenine pathwaysubstance use disordertryptophan

Identifiers

PMID39596587
PMCPMC11594152

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.