Evidence map›Paper›PMID 39596429›Full record

ReviewInternational journal of molecular sciences2024

The Influence of Environmental Exposure to Xenoestrogens on the Risk of Cancer Development.

Martyna Gachowska, Alicja Dąbrowska, Bartosz Wilczyński, Jacek Kuźnicki, Natalia Sauer, Wojciech Szlasa, Christopher Kobierzycki, Zofia Łapińska, Julita Kulbacka

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Martyna GachowskaFaculty of Medicine, Wroclaw Medical University, Pasteura 1, 50-367 Wroclaw, Poland.ORCID 0000-0003-0749-2098
Alicja DąbrowskaFaculty of Medicine, Wroclaw Medical University, Pasteura 1, 50-367 Wroclaw, Poland.ORCID 0000-0001-8610-107X
Bartosz WilczyńskiFaculty of Medicine, Wroclaw Medical University, Pasteura 1, 50-367 Wroclaw, Poland.ORCID 0000-0002-9624-6309
Jacek KuźnickiFaculty of Medicine, Wroclaw Medical University, Pasteura 1, 50-367 Wroclaw, Poland.
Natalia SauerDepartment of Clinical Pharmacology, Faculty of Pharmacy, Wroclaw Medical University, Borowska 211A, 50-556 Wroclaw, Poland.ORCID 0000-0002-1898-3952
Wojciech SzlasaDepartment of Molecular and Cellular Biology, Faculty of Pharmacy, Wroclaw Medical University, Borowska 211A, 50-556 Wroclaw, Poland.
Christopher KobierzyckiDivision of Histology and Embryology, Department of Human Morphology and Embryology, Wroclaw Medical University, 50-368 Wroclaw, Poland.ORCID 0000-0001-8023-8585
Zofia ŁapińskaDepartment of Molecular and Cellular Biology, Faculty of Pharmacy, Wroclaw Medical University, Borowska 211A, 50-556 Wroclaw, Poland.ORCID 0000-0001-5070-2746
Julita KulbackaDepartment of Molecular and Cellular Biology, Faculty of Pharmacy, Wroclaw Medical University, Borowska 211A, 50-556 Wroclaw, Poland.ORCID 0000-0001-8272-5440

Funding

Statutory Subsidy Funds of the Department of Molecular and Cellular Biology SUBZ.D260.24.076
6 · The paper itself

Abstract

Xenoestrogens (XEs) are a group of exogenous substances that may interfere with the functioning of the endocrine system. They may mimic the function of estrogens, and their sources are plants, water or dust, plastic, chemical agents, and some drugs. Thus, people are highly exposed to their actions. Together with the development of industry, the number of XEs in our environment increases. They interact directly with estrogen receptors, disrupting the transmission of cellular signals. It is proven that XEs exhibit clinical application in e.g., menopause hormone therapy, but some studies observed that intense exposure to XEs leads to the progression of various cancers. Moreover, these substances exhibit the ability to cross the placental barrier, therefore, prenatal exposure may disturb fetus development. Due to the wide range of effects resulting from the biological activity of these substances, there is a need for this knowledge to be systematized. This review aims to comprehensively assess the environmental sources of XEs and their role in increasing cancer risk, focusing on current evidence of their biological and pathological impacts.

Indexed as

Endocrine DisruptorsEnvironmental ExposureNeoplasmsAnimalsEnvironmental PollutantsEstrogensFemaleHumansReceptors, EstrogenEndocrine DisruptorsEnvironmental PollutantsEstrogensReceptors, Estrogenenvironmental exposureestrogensisoflavonespesticidesxenoestrogens

Identifiers

PMID39596429
PMCPMC11594813

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.