Evidence map›Paper›PMID 39596393›Full record

ArticleInternational journal of molecular sciences2024

Microsomal Prostaglandin E Synthase-1 Controls Colonic Prostaglandin E

Fumiaki Kojima, Yuka Hioki, Hiroki Sekiya, Hitoshi Kashiwagi, Yoshiko Iizuka, Kei Eto, Shotaro Maehana, Fumitaka Kawakami, Makoto Kubo, Hitoshi Ishibashi and 1 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Fumiaki KojimaDepartment of Pharmacology, Kitasato University School of Allied Health Sciences, Sagamihara 252-0373, Japan.ORCID 0000-0002-5160-1493
Yuka HiokiDepartment of Pharmacology, Kitasato University School of Allied Health Sciences, Sagamihara 252-0373, Japan.
Hiroki SekiyaDepartment of Pharmacology, Kitasato University School of Allied Health Sciences, Sagamihara 252-0373, Japan.
Hitoshi KashiwagiFaculty of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan.ORCID 0000-0001-6385-9988
Yoshiko IizukaRegenerative Medicine and Cell Design Research Facility, Sagamihara 252-0373, Japan.
Kei EtoRegenerative Medicine and Cell Design Research Facility, Sagamihara 252-0373, Japan.
Shotaro MaehanaRegenerative Medicine and Cell Design Research Facility, Sagamihara 252-0373, Japan.
Fumitaka KawakamiDepartment of Regulation Biochemistry, Kitasato University Graduate School of Medical Sciences, Sagamihara 252-0373, Japan.ORCID 0000-0002-8781-2516
Makoto KuboRegenerative Medicine and Cell Design Research Facility, Sagamihara 252-0373, Japan.ORCID 0000-0001-8264-1343
Hitoshi IshibashiRegenerative Medicine and Cell Design Research Facility, Sagamihara 252-0373, Japan.
Takafumi IchikawaDepartment of Regulation Biochemistry, Kitasato University Graduate School of Medical Sciences, Sagamihara 252-0373, Japan.

Funding

JSPS KAKENHI 21K06603Kitasato University Graduate School of Medical Sciences Integrative Research Program 2017-2018Kitasato University Graduate School of Medical Sciences Student Research Program 2017-2018Kitasato University Graduate School of Medical Sciences Student Research Program 2022-2023Kitasato University School of Allied Health Sciences 2015-1033Kitasato University School of Allied Health Sciences 2016-1011Kitasato University School of Allied Health Sciences 2017-1019Regenerative Medicine and Cell Design Research Facility Research Program 2018
6 · The paper itself

Abstract

Microsomal prostaglandin E synthase-1 (mPGES-1) is an isozyme of the prostaglandin (PG) E synthase that acts downstream of cyclooxygenase and catalyzes the conversion of PGH

Indexed as

ColitisColonDinoprostoneProstaglandin-E SynthasesTrinitrobenzenesulfonic AcidAnimalsDisease Models, AnimalInterferon-gammaInterleukin-17MaleMiceMice, Inbred C57BLMice, KnockoutMicrosomesDinoprostoneInterferon-gammaInterleukin-17Prostaglandin-E SynthasesPtges protein, mouseTrinitrobenzenesulfonic Acidcolitiscyclooxygenaseinflammatory bowel diseaseprostaglandin E2prostaglandin E synthaseTh17 and Th1 cytokines

Identifiers

PMID39596393
PMCPMC11594388

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.