Evidence map›Paper›PMID 39596377›Full record

ArticleInternational journal of molecular sciences2024

Silencing Multiple Crustacean Hyperglycaemic Hormone-Encoding Genes in the Redclaw Crayfish

Nickolis Black, Thomas M Banks, Susan Glendinning, Gourab Chowdhury, Donald L Mykles, Tomer Ventura

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Nickolis BlackCentre for Bioinnovation, University of the Sunshine Coast, Sippy Downs, QLD 4556, Australia.
Thomas M BanksCentre for Bioinnovation, University of the Sunshine Coast, Sippy Downs, QLD 4556, Australia.
Susan GlendinningCentre for Bioinnovation, University of the Sunshine Coast, Sippy Downs, QLD 4556, Australia.ORCID 0000-0002-1843-8954
Gourab ChowdhuryCentre for Bioinnovation, University of the Sunshine Coast, Sippy Downs, QLD 4556, Australia.ORCID 0000-0002-9321-4395
Donald L MyklesDepartment of Biology, Colorado State University, Fort Collins, CO 80523, USA.ORCID 0000-0003-4030-2575
Tomer VenturaCentre for Bioinnovation, University of the Sunshine Coast, Sippy Downs, QLD 4556, Australia.ORCID 0000-0002-0777-2367

Funding

National Science Foundation IOS-1922701
6 · The paper itself

Abstract

RNA interference (RNAi)-based biotechnology has been previously implemented in decapod crustaceans. Unlike traditional RNAi methodologies that investigate single gene silencing, we employed a multigene silencing approach in decapods based on chimeric double-stranded RNA (dsRNA) molecules coined 'gene blocks'. Two dsRNA constructs, each targeting three genes of the crustacean hyperglycaemic hormone (CHH) superfamily of neuropeptides, were produced: Type II construct targeting

Indexed as

Arthropod ProteinsAstacoideaInvertebrate HormonesMoltingRNA InterferenceAnimalsEcdysteroneGene SilencingHemolymphNerve Tissue ProteinsRNA, Double-StrandedArthropod ProteinsEcdysteronehyperglycemic hormone, crustaceanInvertebrate HormonesNerve Tissue ProteinsRNA, Double-Strandedchimeric dsRNAcrustaceansdecapodsgene blocksmultigene silencingRNA interference

Identifiers

PMID39596377
PMCPMC11594818

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.