Evidence map›Paper›PMID 39596283›Full record

ArticleInternational journal of molecular sciences2024

Erucin, a Natural Isothiocyanate, Prevents Polyglutamine-Induced Toxicity in

Martina Balducci, Julia Tortajada Pérez, Cristina Trujillo Del Río, Mar Collado Pérez, Andrea Del Valle Carranza, Ana Pilar Gomez Escribano, Rafael P Vázquez-Manrique, Andrea Tarozzi

Abstract read
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In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Martina BalducciDepartment for Life Quality Studies, University of Bologna, 47921 Rimini, Italy.ORCID 0000-0002-9657-6340
Julia Tortajada PérezLaboratory of Molecular, Cellular and Genomic Biomedicine, Instituto de Investigación Sanitaria La Fe, 46012 Valencia, Spain.
Cristina Trujillo Del RíoLaboratory of Molecular, Cellular and Genomic Biomedicine, Instituto de Investigación Sanitaria La Fe, 46012 Valencia, Spain.
Mar Collado PérezLaboratory of Molecular, Cellular and Genomic Biomedicine, Instituto de Investigación Sanitaria La Fe, 46012 Valencia, Spain.
Andrea Del Valle CarranzaLaboratory of Molecular, Cellular and Genomic Biomedicine, Instituto de Investigación Sanitaria La Fe, 46012 Valencia, Spain.ORCID 0000-0003-2823-2869
Ana Pilar Gomez EscribanoLaboratory of Molecular, Cellular and Genomic Biomedicine, Instituto de Investigación Sanitaria La Fe, 46012 Valencia, Spain.ORCID 0000-0003-4391-5932
Rafael P Vázquez-ManriqueLaboratory of Molecular, Cellular and Genomic Biomedicine, Instituto de Investigación Sanitaria La Fe, 46012 Valencia, Spain.ORCID 0000-0002-1594-0033
Andrea TarozziDepartment for Life Quality Studies, University of Bologna, 47921 Rimini, Italy.ORCID 0000-0001-7983-8575

Funding

Department for Life Quality Studies of University of Bologna, Marco Polo Prot. N 0000669, 29/08/2023Generalitat Valenciana ACIF/2020/366, CIACIF/2022/421 and CIACIF/2022/422Instituto de Salud Carlos III PI20/00114 and PI23/00455Marie-Sklodowska Curie grant PCI2021-122099-2B
6 · The paper itself

Abstract

Several neurodegenerative diseases (NDDs), such as Huntington's disease, six of the spinocerebellar ataxias, dentatorubral-pallidoluysian atrophy, and spinobulbar muscular atrophy, are caused by abnormally long polyglutamine (polyQ) tracts. Natural compounds capable of alleviating polyQ-induced toxicity are currently of great interest. In this work, we investigated the modulatory effect against polyQ neurotoxic aggregates exerted by erucin (ERN), an isothiocyanate naturally present in its precursor glucoerucin in rocket salad leaves and in its oxidized form, sulforaphane (SFN), in broccoli. Using

Indexed as

AMP-Activated Protein KinasesCaenorhabditis elegansCaenorhabditis elegans ProteinsForkhead Transcription FactorsIsothiocyanatesPeptidesSignal TransductionAnimalsSulfidesSulfoxidesThiocyanatesAAK-2 protein, C elegansAMP-Activated Protein KinasesCaenorhabditis elegans Proteinsdaf-16 protein, C eleganserucinForkhead Transcription FactorsIsothiocyanatesPeptidespolyglutamineSulfidesSulfoxidesThiocyanatesAMPKCaenorhabditis elegansdaf-16/FOXOerucinneuroprotectionpolyQ toxicity

Identifiers

PMID39596283
PMCPMC11594550

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.