Evidence map›Paper›PMID 39596277›Full record

ArticleInternational journal of molecular sciences2024

Dual Photonics Probing of Nano- to Submicron-Scale Structural Alterations in Human Brain Tissues/Cells and Chromatin/DNA with the Progression of Alzheimer's Disease.

Fatemah Alharthi, Ishmael Apachigawo, Dhruvil Solanki, Sazzad Khan, Himanshi Singh, Mohammad Moshahid Khan, Prabhakar Pradhan

Abstract read
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In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Fatemah AlharthiDepartment of Physics and Astronomy, Mississippi State University, Mississippi State, MS 39762, USA.ORCID 0009-0004-0330-4744
Ishmael ApachigawoDepartment of Physics and Astronomy, Mississippi State University, Mississippi State, MS 39762, USA.ORCID 0009-0006-9791-8898
Dhruvil SolankiDepartment of Physics and Astronomy, Mississippi State University, Mississippi State, MS 39762, USA.ORCID 0009-0006-8507-8668
Sazzad KhanDepartment of Neurology, The University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Himanshi SinghDepartment of Neurology, The University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Mohammad Moshahid KhanDepartment of Neurology, The University of Tennessee Health Science Center, Memphis, TN 38163, USA.ORCID 0000-0003-4679-294X
Prabhakar PradhanDepartment of Physics and Astronomy, Mississippi State University, Mississippi State, MS 39762, USA.ORCID 0000-0003-4363-2326

Funding

Photonics probing of DNA mass density spatial structure for cancer diagnosticsR21CA260147 · NCI · MISSISSIPPI STATE UNIVERSITY · PI PRADHAN, PRABHAKAR · 2021 to 2021
$397k
Development of a novel gene therapy for the treatment of tauopathyR03AG075597 · NIA · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI KHAN, MOHAMMAD MOSHAHID, POURMOTABBED, TAYEBEH · 2022 to 2022
$308k
DOD, USA HT9425-23-1-0043NIH, USA R03AG075597NIH, USA R21CA260147
6 · The paper itself

Abstract

Understanding alterations in structural disorders in tissue/cells/building blocks, such as DNA/chromatin in the human brain, at the nano to submicron level provides us with efficient biomarkers for Alzheimer's detection. Here, we report a dual photonics technique to detect nano- to submicron-scale alterations in brain tissues/cells and DNA/chromatin due to the early to late progression of Alzheimer's disease in humans. Using a recently developed mesoscopic light transport technique, fine-focused nano-sensitive partial wave spectroscopy (PWS), we measure the degree of structural disorder in tissues. Furthermore, the chemical-specific inverse participation ratio technique (IPR) was used to measure the DNA/chromatin structural alterations. The results of the PWS and IPR experiments showed a significant increase in the degree of structural disorder at the nano to submicron scale at different stages of AD relative to their controls for both the tissue/cell and DNA cellular levels. The increase in the structural disorder in cells/tissues and DNA/chromatin in the nuclei can be attributed to higher mass density fluctuations in the tissue and DNA/chromatin damage in the nuclei caused by the rearrangements of macromolecules due to the deposition of the amyloid beta protein and damage in DNA/chromatin with the progress of AD.

Indexed as

Alzheimer DiseaseBrainChromatinDNAAgedAmyloid beta-PeptidesDisease ProgressionFemaleHumansMaleAmyloid beta-PeptidesChromatinDNAAlzheimer’s diseaseconfocal imagingdisorder strengthinverse participation ratio techniquelight scatteringmesoscopic physicspartial wave spectroscopy

Identifiers

PMID39596277
PMCPMC11595041

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.