Evidence map›Paper›PMID 39596232›Full record

ReviewInternational journal of molecular sciences2024

Gut Microbiota and Immune System Dynamics in Parkinson's and Alzheimer's Diseases.

Natasa Kustrimovic, Sahar Balkhi, Giorgia Bilato, Lorenzo Mortara

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Review
  6. Review
  7. Defining reference values for the gut microbiota in a Southern European population.Frontiers in cellular and infection microbiology · 2026
    Article
  8. Article
  9. Review
  10. Review
  11. Review
  12. Article
  13. Genome report of a probioticMicrobiology resource announcements · 2025
    Article
  14. Review
  15. Mitigation ofJournal of microbiology and biotechnology · 2025
    Article
  16. Review
  17. Age-Related Cognitive Decline and Dementia: Interface of Microbiome-Immune-Neuronal Interactions.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025
    Review
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Natasa KustrimovicDepartment of Biotechnology and Life Sciences, University of Insubria, 21100 Varese, Italy.ORCID 0000-0002-5524-5238
Sahar BalkhiImmunology and General Pathology Laboratory, Department of Biotechnology and Life Sciences, University of Insubria, 21100 Varese, Italy.ORCID 0000-0001-8236-2168
Giorgia BilatoImmunology and General Pathology Laboratory, Department of Biotechnology and Life Sciences, University of Insubria, 21100 Varese, Italy.
Lorenzo MortaraImmunology and General Pathology Laboratory, Department of Biotechnology and Life Sciences, University of Insubria, 21100 Varese, Italy.ORCID 0000-0002-4757-7101

Funding

Fondi di Ateneo per la Ricerca University of Insubria, Varese, Italy Fondi di Ateneo per la Ricerca FAR2022 and FAR2023Ministry of Health - IRCCS MultiMedica, Milan, Italy Ricerca Corrente
6 · The paper itself

Abstract

The gut microbiota, a diverse collection of microorganisms in the gastrointestinal tract, plays a critical role in regulating metabolic, immune, and cognitive functions. Disruptions in the composition of these microbial communities, termed dysbiosis, have been linked to various neurodegenerative diseases (NDs), such as Parkinson's disease (PD) and Alzheimer's disease (AD). One of the key pathological features of NDs is neuroinflammation, which involves the activation of microglia and peripheral immune cells. The gut microbiota modulates immune responses through the production of metabolites and interactions with immune cells, influencing the inflammatory processes within the central nervous system. This review explores the impact of gut dysbiosis on neuroinflammation, focusing on the roles of microglia, immune cells, and potential therapeutic strategies targeting the gut microbiota to alleviate neuroinflammatory processes in NDs.

Indexed as

Alzheimer DiseaseDysbiosisGastrointestinal MicrobiomeParkinson DiseaseAnimalsHumansImmune SystemMicrogliaNeuroinflammatory DiseasesAlzheimer’s diseasemicrobiotaneurodegenerative diseasesParkinson’s disease

Identifiers

PMID39596232
PMCPMC11595203

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.