Evidence map›Paper›PMID 39596134›Full record

ArticleInternational journal of molecular sciences2024

Human-Brain-Derived Ischemia-Induced Stem Cell Transplantation Is Associated with a Greater Neurological Functional Improvement Compared with Human-Bone Marrow-Derived Mesenchymal Stem Cell Transplantation in Mice After Stroke.

Shuichi Tanada, Takayuki Nakagomi, Akiko Nakano-Doi, Toshinori Sawano, Shuji Kubo, Yoji Kuramoto, Kazutaka Uchida, Kenichi Yamahara, Nobutaka Doe, Shinichi Yoshimura

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. "Time Is Brain" - for Cell Therapies.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Shuichi TanadaDepartment of Neurosurgery, Hyogo Medical University, 1-1 Mukogawacho, Nishinomiya 663-8501, Japan.
Takayuki NakagomiInstitute for Advanced Medical Sciences, Hyogo Medical University (Nishinomiya Campus), 1-1 Mukogawacho, Nishinomiya 663-8501, Japan.ORCID 0000-0003-2274-410X
Akiko Nakano-DoiInstitute for Advanced Medical Sciences, Hyogo Medical University (Nishinomiya Campus), 1-1 Mukogawacho, Nishinomiya 663-8501, Japan.
Toshinori SawanoDepartment of Biomedical Sciences, Ritsumeikan University, 1-1-1 Nojihigashi, Kusatsu 525-8577, Japan.ORCID 0000-0002-8670-2980
Shuji KuboInstitute for Advanced Medical Sciences, Hyogo Medical University (Nishinomiya Campus), 1-1 Mukogawacho, Nishinomiya 663-8501, Japan.ORCID 0000-0001-7384-4835
Yoji KuramotoDepartment of Neurosurgery, Hyogo Medical University, 1-1 Mukogawacho, Nishinomiya 663-8501, Japan.ORCID 0000-0002-3652-6261
Kazutaka UchidaDepartment of Neurosurgery, Hyogo Medical University, 1-1 Mukogawacho, Nishinomiya 663-8501, Japan.
Kenichi YamaharaInstitute for Advanced Medical Sciences, Hyogo Medical University (Nishinomiya Campus), 1-1 Mukogawacho, Nishinomiya 663-8501, Japan.
Nobutaka DoeDepartment of Rehabilitation, Hyogo Medical University (Kobe Campus), 1-3-6 Minatojima, Chuo-ku, Kobe 650-8530, Japan.
Shinichi YoshimuraDepartment of Neurosurgery, Hyogo Medical University, 1-1 Mukogawacho, Nishinomiya 663-8501, Japan.ORCID 0000-0001-9932-2162

Funding

Hyogo Innovative Challenge (2022) NoneHyogo Medical University Grant for Research Promotion (2023) NoneJapan Agency for Medical Research and Development (AMED) 21nk0101538h0002Japan Society for the Promotion of Science (JSPS) KAKENHI 15K06723Japan Society for the Promotion of Science (JSPS) KAKENHI 18K07380the Grant-in-Aid for Graduate Students, Hyogo Medical University (2024) Nonethe Grant-in-Aid from the Japanese Society of Cerebral Blood Flow and Metabolism (2019) None
6 · The paper itself

Abstract

The transplantation of injury/ischemia-induced stem cells (iSCs) extracted from post-stroke human brains can improve the neurological functions of mice after stroke. However, the usefulness of iSCs as an alternative stem cell source remains unclear. The current study aimed to assess the efficacy of iSC and mesenchymal stem cell (MSC) transplantation. In this experiment, equal numbers of human brain-derived iSCs (h-iSCs) (5.0 × 10

Indexed as

Brain IschemiaMesenchymal Stem CellsMesenchymal Stem Cell TransplantationStrokeAnimalsBrainDisease Models, AnimalHumansInfarction, Middle Cerebral ArteryMaleMiceMice, Inbred C57BLNeural Stem CellsRecovery of Functioncell transplantationinjury/ischemia-induced stem cellsischemic strokemesenchymal stem cellsneural stem/progenitor cellsneurological function

Identifiers

PMID39596134
PMCPMC11593343

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.