Evidence map›Paper›PMID 39596118›Full record

ArticleInternational journal of molecular sciences2024

FAAH Inhibition Counteracts Neuroinflammation via Autophagy Recovery in AD Models.

Federica Armeli, Roberto Coccurello, Giacomo Giacovazzo, Beatrice Mengoni, Ilaria Paoletti, Sergio Oddi, Mauro Maccarrone, Rita Businaro

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Neurotransmitter Systems in Alzheimer's Disease.Current issues in molecular biology · 2026
    Review
  3. Review
  4. Article
  5. International journal of molecular sciences · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Federica ArmeliDepartment of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, 04100 Latina, Italy.ORCID 0000-0002-4981-3374
Roberto CoccurelloEuropean Brain Research Center, Santa Lucia Foundation IRCCS, 00143 Rome, Italy.ORCID 0000-0001-7059-7015
Giacomo GiacovazzoEuropean Brain Research Center, Santa Lucia Foundation IRCCS, 00143 Rome, Italy.
Beatrice MengoniDepartment of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, 04100 Latina, Italy.ORCID 0009-0005-5245-1684
Ilaria PaolettiEuropean Brain Research Center, Santa Lucia Foundation IRCCS, 00143 Rome, Italy.
Sergio OddiEuropean Brain Research Center, Santa Lucia Foundation IRCCS, 00143 Rome, Italy.ORCID 0000-0002-6217-698X
Mauro MaccarroneEuropean Brain Research Center, Santa Lucia Foundation IRCCS, 00143 Rome, Italy.ORCID 0000-0002-3990-2963
Rita BusinaroDepartment of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, 04100 Latina, Italy.ORCID 0000-0002-7890-8524

Funding

Ministry of University and Research (MUR), Sapienza University of Rome PRIN 2017- 2017BTHJ4R, Ateneo 2020 RM120172B745088B, Ateneo 2021 RM12117A8166CD9
6 · The paper itself

Abstract

Endocannabinoids have attracted great interest for their ability to counteract the neuroinflammation underlying Alzheimer's disease (AD). Our study aimed at evaluating whether this activity was also due to a rebalance of autophagic mechanisms in cellular and animal models of AD. We supplied URB597, an inhibitor of Fatty-Acid Amide Hydrolase (FAAH), the degradation enzyme of anandamide, to microglial cultures treated with Aβ

Indexed as

Alzheimer DiseaseAmidohydrolasesAutophagyBenzamidesCarbamatesDisease Models, AnimalMice, TransgenicMicrogliaNeuroinflammatory DiseasesAnimalsEndocannabinoidsFatty Acid Amide HydrolasesMiceTOR Serine-Threonine KinasesAmidohydrolasesBenzamidesCarbamatescyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl esterEndocannabinoidsFatty Acid Amide HydrolasesTOR Serine-Threonine KinasesAlzheimer’s disease (AD)ATG7autophagyBDNFendocannabinoidsfatty acid amide hydrolasemicrogliamTORneuroinflammationURB597

Identifiers

PMID39596118
PMCPMC11593522

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.