Evidence map›Paper›PMID 39596084›Full record

ArticleInternational journal of molecular sciences2024

A Small Intestinal Helminth Infection Alters Colonic Mucus and Shapes the Colonic Mucus Microbiome.

Thomas C Mules, Francesco Vacca, Alissa Cait, Bibek Yumnam, Alfonso Schmidt, Brittany Lavender, Kate Maclean, Sophia-Louise Noble, Olivier Gasser, Mali Camberis and 2 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Frontiers in cellular and infection microbiology · 2026
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Thomas C MulesMalaghan Institute of Medical Research, Kelburn, Wellington 6012, New Zealand.ORCID 0000-0002-3943-9198
Francesco VaccaMalaghan Institute of Medical Research, Kelburn, Wellington 6012, New Zealand.ORCID 0000-0001-6808-5221
Alissa CaitMalaghan Institute of Medical Research, Kelburn, Wellington 6012, New Zealand.
Bibek YumnamMalaghan Institute of Medical Research, Kelburn, Wellington 6012, New Zealand.
Alfonso SchmidtHugh Green Technology Centre, Malaghan Institute of Medical Research, Wellington 6012, New Zealand.ORCID 0000-0002-7213-7546
Brittany LavenderMalaghan Institute of Medical Research, Kelburn, Wellington 6012, New Zealand.ORCID 0000-0002-8155-9193
Kate MacleanMalaghan Institute of Medical Research, Kelburn, Wellington 6012, New Zealand.ORCID 0000-0001-7421-5731
Sophia-Louise NobleMalaghan Institute of Medical Research, Kelburn, Wellington 6012, New Zealand.ORCID 0000-0002-4896-7160
Olivier GasserMalaghan Institute of Medical Research, Kelburn, Wellington 6012, New Zealand.ORCID 0000-0002-8235-2274
Mali CamberisMalaghan Institute of Medical Research, Kelburn, Wellington 6012, New Zealand.
Graham Le GrosMalaghan Institute of Medical Research, Kelburn, Wellington 6012, New Zealand.
Stephen InnsDepartment of Medicine, University of Otago, 23A Mein St., Newtown, Wellington 6242, New Zealand.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Infecting humans with controlled doses of small intestinal helminths, such as human hookworm, is proposed as a therapy for the colonic inflammatory disease ulcerative colitis. Strengthening the colonic mucus barrier is a potential mechanism by which small intestinal helminths could treat ulcerative colitis. In this study, we compare C57BL/6 mice infected with the small intestinal helminth

Indexed as

ColonGastrointestinal MicrobiomeMice, Inbred C57BLMice, KnockoutAnimalsColitis, UlcerativeEubacterialesFemaleGoblet CellsHumansIntercellular Signaling Peptides and ProteinsInterleukin-13Intestinal MucosaIntestine, SmallMaleMiceIntercellular Signaling Peptides and ProteinsInterleukin-13MucinsRetnlb protein, mousehelminthhookwormintestinal barriermicrobiomemucustrefoil factor

Identifiers

PMID39596084
PMCPMC11593901

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.