Evidence map›Paper›PMID 39596049›Full record

ReviewInternational journal of molecular sciences2024

Prokaryote- and Eukaryote-Based Expression Systems: Advances in Post-Pandemic Viral Antigen Production for Vaccines.

Nelli S Khudainazarova, Dmitriy L Granovskiy, Olga A Kondakova, Ekaterina M Ryabchevskaya, Angelina O Kovalenko, Ekaterina A Evtushenko, Marina V Arkhipenko, Nikolai A Nikitin, Olga V Karpova

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Nelli S KhudainazarovaDepartment of Virology, Faculty of Biology, Lomonosov Moscow State University, 119991 Moscow, Russia.
Dmitriy L GranovskiyDepartment of Virology, Faculty of Biology, Lomonosov Moscow State University, 119991 Moscow, Russia.
Olga A KondakovaDepartment of Virology, Faculty of Biology, Lomonosov Moscow State University, 119991 Moscow, Russia.ORCID 0000-0001-5134-6624
Ekaterina M RyabchevskayaDepartment of Virology, Faculty of Biology, Lomonosov Moscow State University, 119991 Moscow, Russia.ORCID 0000-0003-2683-8285
Angelina O KovalenkoDepartment of Virology, Faculty of Biology, Lomonosov Moscow State University, 119991 Moscow, Russia.ORCID 0000-0001-9786-7652
Ekaterina A EvtushenkoDepartment of Virology, Faculty of Biology, Lomonosov Moscow State University, 119991 Moscow, Russia.ORCID 0000-0002-0679-6818
Marina V ArkhipenkoDepartment of Virology, Faculty of Biology, Lomonosov Moscow State University, 119991 Moscow, Russia.
Nikolai A NikitinDepartment of Virology, Faculty of Biology, Lomonosov Moscow State University, 119991 Moscow, Russia.ORCID 0000-0001-9626-2336
Olga V KarpovaDepartment of Virology, Faculty of Biology, Lomonosov Moscow State University, 119991 Moscow, Russia.ORCID 0000-0002-0605-9033

Funding

Russian Science Foundation 24-14-00032
6 · The paper itself

Abstract

This review addresses the ongoing global challenge posed by emerging and evolving viral diseases, underscoring the need for innovative vaccine development strategies. It focuses on the modern approaches to creating vaccines based on recombinant proteins produced in different expression systems, including bacteria, yeast, plants, insects, and mammals. This review analyses the advantages, limitations, and applications of these expression systems for producing vaccine antigens, as well as strategies for designing safer, more effective, and potentially 'universal' antigens. The review discusses the development of vaccines for a range of viral diseases, excluding SARS-CoV-2, which has already been extensively studied. The authors present these findings with the aim of contributing to ongoing research and advancing the development of antiviral vaccines.

Indexed as

Antigens, ViralViral VaccinesAnimalsBacteriaHumansPandemicsProkaryotic CellsRecombinant ProteinsSARS-CoV-2Vaccine DevelopmentAntigens, ViralRecombinant ProteinsViral Vaccinesantigen designbiopharmaceutical productionexpression systemrecombinant antigenrecombinant proteinrecombinant vaccine platformssubunit vaccinesvaccine antigenvaccine developmentvirus-like particles

Identifiers

PMID39596049
PMCPMC11594041

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.