Evidence map›Paper›PMID 39596003›Full record

ArticleInternational journal of molecular sciences2024

NEDD4L Suppresses Proliferation and Promotes Apoptosis by Ubiquitinating RAC2 Expression and Acts as a Prognostic Biomarker in Clear Cell Renal Cell Carcinoma.

Manlong Qi, Jianqiao Tu, Rong He, Xiang Fei, Yanyan Zhao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Manlong QiDepartment of Clinical Genetics, The Affiliated Shengjing Hospital, China Medical University, Shenyang 110004, China.
Jianqiao TuDepartment of Clinical Genetics, The Affiliated Shengjing Hospital, China Medical University, Shenyang 110004, China.
Rong HeDepartment of Clinical Genetics, The Affiliated Shengjing Hospital, China Medical University, Shenyang 110004, China.
Xiang FeiDepartment of Urology, The Affiliated Shengjing Hospital, China Medical University, Shenyang 110004, China.
Yanyan ZhaoDepartment of Clinical Genetics, The Affiliated Shengjing Hospital, China Medical University, Shenyang 110004, China.

Funding

Natural Science Foundation of Liaoning Province 2019-MS-371
6 · The paper itself

Abstract

Neural precursor cell expressed developmentally down-regulated 4-like (NEDD4L) is an HECT (homologous to E6AP C terminus)-type E3 ubiquitin ligase. As previously documented, bioinformatics analysis revealed

Indexed as

ApoptosisBiomarkers, TumorCarcinoma, Renal CellCell ProliferationGene Expression Regulation, NeoplasticKidney NeoplasmsNedd4 Ubiquitin Protein LigasesRAC2 GTP-Binding ProteinUbiquitinationCell Line, TumorCell MovementFemaleHumansMalePrognosisrac GTP-Binding ProteinsBiomarkers, TumorNedd4L protein, humanNedd4 Ubiquitin Protein LigasesRAC2 GTP-Binding Proteinrac GTP-Binding ProteinsNEDD4LRAC2renal cell carcinomaubiquitination

Identifiers

PMID39596003
PMCPMC11594477

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.