Evidence map›Paper›PMID 39595917›Full record

ArticleBrain sciences2024

Window Coverage and Liquid Biopsy in the First-Line Therapy of Severe Sudden Sensorineural Hearing Loss.

Alexander Kilgue, Rayoung Kim, Lars-Uwe Scholtz, Conrad Riemann, Christoph J Pfeiffer, Matthias Schürmann, Ingo Todt

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Alexander KilgueDepartment of Otolaryngology, Head and Neck Surgery, Campus Klinikum Bielefeld Mitte, Medical School OWL, Bielefeld University, Teutoburger Str. 50, 33604 Bielefeld, Germany.
Rayoung KimDepartment of Otolaryngology, Head and Neck Surgery, Campus Klinikum Bielefeld Mitte, Medical School OWL, Bielefeld University, Teutoburger Str. 50, 33604 Bielefeld, Germany.
Lars-Uwe ScholtzDepartment of Otolaryngology, Head and Neck Surgery, Campus Klinikum Bielefeld Mitte, Medical School OWL, Bielefeld University, Teutoburger Str. 50, 33604 Bielefeld, Germany.
Conrad RiemannDepartment of Otolaryngology, Head and Neck Surgery, Campus Klinikum Bielefeld Mitte, Medical School OWL, Bielefeld University, Teutoburger Str. 50, 33604 Bielefeld, Germany.
Christoph J PfeifferDepartment of Otolaryngology, Head and Neck Surgery, Campus Klinikum Bielefeld Mitte, Medical School OWL, Bielefeld University, Teutoburger Str. 50, 33604 Bielefeld, Germany.
Matthias SchürmannDepartment of Otolaryngology, Head and Neck Surgery, Campus Klinikum Bielefeld Mitte, Medical School OWL, Bielefeld University, Teutoburger Str. 50, 33604 Bielefeld, Germany.ORCID 0000-0002-1541-3727
Ingo TodtDepartment of Otolaryngology, Head and Neck Surgery, Campus Klinikum Bielefeld Mitte, Medical School OWL, Bielefeld University, Teutoburger Str. 50, 33604 Bielefeld, Germany.ORCID 0000-0002-4161-8304

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionBased on clinical practice guidelines, the application of corticosteroids as a first-line therapy is common. Although sudden sensorineural hearing loss (SSHL) etiology is primarily idiopathic, hearing loss can result from a perilymphatic fistula (PLF). Recent findings show evidence of a specific rate of PLF based on a cochlin-tomoprotein (CTP) detection test. Based on this rate of PLF treatment, the concepts of SSNHL need to be re-evaluated. The present study aimed to evaluate CTP in SSNHL patients and compare pre-surgical and post-surgical pure tone hearing thresholds after round and oval window sealing as first-line treatment. MATERIAL AND

methodsA total of 30 patients with unilateral SSNHL with a pure tone average (PTA) (4 Freq. of 60 dB or more were enrolled in a prospective study. All patients underwent tympanoscopy for middle ear exploration as a first-line treatment. After intraoperative observation of a possible PLF, all patients obtained middle ear lavage to gain CTP samples for following ELISA-based CTP detection tests. All patients received round window and oval window sealing with fascia. PTA hearing thresholds were analyzed post-surgically 3 weeks after treatment based on 4-frequency bone conduction (BC).

resultsThe average preoperative pure tone BC threshold was 97.7 dB compared with the 69 dB postoperative BC threshold. Mean BC improved by 20.3 dB after middle ear exploration and window sealing. A total of 56% (17 of 30) of patients recovered at least 10 dB. The middle ear cochlin-tomoprotein detection rate was 70% positive.

conclusionsThe combination of early tympanoscopy and inner ear-specific cochlin-tomoprotein as a detection tool for suspected PLF showed evidence of PLF as a key causative in SSNHL.

Indexed as

cochlin-tomoprotein (CTP)perilymphatic fistula (PLF)sudden sensorineural hearing loss (SSNHL)tympanoscopy

Identifiers

PMID39595917
PMCPMC11592200

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