Evidence map›Paper›PMID 39595838›Full record

ArticleBrain sciences2024

The Adult Changes in Thought (ACT) Medical Records Abstraction Project: A Resource for Research on Biological, Psychosocial and Behavioral Factors on the Aging Brain and Alzheimer's Disease and Related Dementias.

Nicole M Gatto, Anne Renz, Sarah E Tom, Mary Lyons, Jennifer A Macuiba, Tammy S Dodd, Bonnie K Lind, Shelly L Gray, Kelly Meyers, Eric B Larson and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Genetically proxied blood pressure, vascular brain injury, and Alzheimer's disease pathology.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Nicole M GattoKaiser Permanente Washington Health Research Institute, Seattle, WA 98101, USA.
Anne RenzKaiser Permanente Washington Health Research Institute, Seattle, WA 98101, USA.
Sarah E TomColumbia University Irving Medical Center, New York, NY 10032, USA.
Mary LyonsKaiser Permanente Washington Health Research Institute, Seattle, WA 98101, USA.
Jennifer A MacuibaKaiser Permanente Washington Health Research Institute, Seattle, WA 98101, USA.
Tammy S DoddKaiser Permanente Washington Health Research Institute, Seattle, WA 98101, USA.
Bonnie K LindKaiser Permanente Washington Health Research Institute, Seattle, WA 98101, USA.
Shelly L GraySchool of Pharmacy, University of Washington, Seattle, WA 98102, USA.
Kelly MeyersKaiser Permanente Washington Health Research Institute, Seattle, WA 98101, USA.
Eric B LarsonKaiser Permanente Washington Health Research Institute, Seattle, WA 98101, USA.ORCID 0000-0003-1108-6164
Jennifer C NelsonKaiser Permanente Washington Health Research Institute, Seattle, WA 98101, USA.
Linda K McEvoyKaiser Permanente Washington Health Research Institute, Seattle, WA 98101, USA.
Sundary SankaranKaiser Permanente Washington Health Research Institute, Seattle, WA 98101, USA.
Dustin KeyKaiser Permanente Washington Health Research Institute, Seattle, WA 98101, USA.
Jeremiah A LitondoKaiser Permanente Washington Health Research Institute, Seattle, WA 98101, USA.
Paul K CraneSchool of Medicine, University of Washington, Seattle, WA 98195, USA.

Funding

Translational pharmacoepidemiology: neuroprotection and neurotoxicity of antihypertensives and strong anticholinergicsU19AG066567 · NIA · KAISER FOUNDATION RESEARCH INSTITUTE · PI Christine L MacDonald · 2021 to 2026
$80.4M
Furthering scientific understanding of mechanisms underlying resilience to the effects of AD pathology by incorporating state of the art quantification of gliosis, inflammation, & synaptic toxicityU01AG006781 · NIA · UNIVERSITY OF WASHINGTON · PI CRANE, PAUL K, LARSON, ERIC B · 1986 to 2020
$39.3M
NIA NIH HHS U01 AG006781NIA NIH HHS U01AG006781NIA NIH HHS U19 AG066567NIA NIH HHS U19AG066567
6 · The paper itself

Abstract

backgroundAdult Changes in Thought (ACT), a prospective cohort study, enrolls older adult members of Kaiser Permanente Washington. We describe an ambitious project to abstract medical records facilitating epidemiological investigation.

methodsAbstracted data include medications; laboratory results; women's health; blood pressure; physical injuries; cardiovascular, neurological, psychiatric and other medical conditions.

resultsOf 1419 of 5763 participants with completed abstractions, 1387 (97.7%) were deceased; 602 (42.4%) were diagnosed with Alzheimer's Disease and Related Dementias; 985 (69.4%) had a brain autopsy. Each participant had an average of 34.3 (SD = 13.4) years of data abstracted. Over 64% had pharmacy data preceding 1977; 87.5% had laboratory data preceding 1988. Stroke, anxiety, depression and confusion during hospitalization were common among participants diagnosed with dementia.

conclusionsMedical records are transformed into data for analyses with outcomes derived from other ACT data. We provide detailed, unparalleled longitudinal clinical data to support a variety of epidemiological research on clinical-pathological correlations.

Indexed as

Alzheimer’s diseasechart abstractionchart datacomorbiditiesdementiaelectronic health record datahistorical data

Identifiers

PMID39595838
PMCPMC11592130

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.