Evidence map›Paper›PMID 39595692›Full record

ArticleInternational journal of environmental research and public health2024

Long-Term Physical Activity Mitigates Inflammaging Progression in Older Adults Amidst the COVID-19 Pandemic.

Carlos André Freitas Dos Santos, Ariane Nardy, Renato Jimenez Gomes, Brenda Rodrigues Silva, Fernanda Rodrigues Monteiro, Marcelo Rossi, Jônatas Bussador do Amaral, Vitória Paixão, Mauro Walter Vaisberg, Gislene Rocha Amirato and 7 more

Abstract read
In one paragraph

Article in International journal of environmental research and public health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Inflammaging and Cardiovascular Risk in Old Women.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2026
    Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Carlos André Freitas Dos SantosPostgraduate Program in Translational Medicine, Department of Medicine, Paulista School of Medicine, Federal University of São Paulo (UNIFESP), São Paulo 04039-002, Brazil.ORCID 0000-0001-5822-7791
Ariane NardyPostgraduate Program in Health Science, Santo Amaro University (UNISA), São Paulo 04829-300, Brazil.
Renato Jimenez GomesPostgraduate Program in Health Science, Santo Amaro University (UNISA), São Paulo 04829-300, Brazil.
Brenda Rodrigues SilvaPostgraduate Program in Health Science, Santo Amaro University (UNISA), São Paulo 04829-300, Brazil.
Fernanda Rodrigues MonteiroPostgraduate Program in Health Science, Santo Amaro University (UNISA), São Paulo 04829-300, Brazil.ORCID 0000-0001-9413-447X
Marcelo RossiPostgraduate Program in Health Science, Santo Amaro University (UNISA), São Paulo 04829-300, Brazil.
Jônatas Bussador do AmaralENT Research Laboratory, Department of Otorhinolaryngology-Head and Neck Surgery, Federal University of Sao Paulo (UNIFESP), São Paulo 04021-001, Brazil.ORCID 0000-0001-5819-0474
Vitória PaixãoENT Research Laboratory, Department of Otorhinolaryngology-Head and Neck Surgery, Federal University of Sao Paulo (UNIFESP), São Paulo 04021-001, Brazil.ORCID 0000-0002-3537-4606
Mauro Walter VaisbergENT Research Laboratory, Department of Otorhinolaryngology-Head and Neck Surgery, Federal University of Sao Paulo (UNIFESP), São Paulo 04021-001, Brazil.ORCID 0000-0003-0292-3792
Gislene Rocha AmiratoMane Garrincha Sports Education Center, Sports Department of the Municipality of Sao Paulo (SEME), São Paulo 04039-034, Brazil.
Rodolfo P VieiraPost-Graduation Program in Science of Human and Rehabilitation, Federal University of São Paulo (UNIFESP), Santos 11010-150, Brazil.
Juliana de Melo Batista Dos SantosDepartment of Physical Therapy, School of Medicine, University of São Paulo, São Paulo 05360-000, Brazil.
Guilherme Eustaquio FurtadoPolytechnic Institute of Coimbra, Applied Research Institute, 3045-093 Coimbra, Portugal.ORCID 0000-0001-8327-1567
Ana Paula RibeiroPostgraduate Program in Health Science, Santo Amaro University (UNISA), São Paulo 04829-300, Brazil.
Patrícia Colombo-SouzaPostgraduate Program in Health Science, Santo Amaro University (UNISA), São Paulo 04829-300, Brazil.
Alessandro Ferrari JacintoPostgraduate Program in Translational Medicine, Department of Medicine, Paulista School of Medicine, Federal University of São Paulo (UNIFESP), São Paulo 04039-002, Brazil.ORCID 0000-0002-1977-5880
Andre Luis Lacerda BachiPostgraduate Program in Health Science, Santo Amaro University (UNISA), São Paulo 04829-300, Brazil.ORCID 0000-0001-8266-1416

Funding

Fundação de Amparo à Pesquisa do Estado de São Paulo no. 2019/14115-0 and 2022/02030-3 (ALLB)National Council for Scientific and Technological Development 305008/2022-6 (CNPq-PQ2) (ALLB)
6 · The paper itself

Abstract

backgroundInflammaging and physical performance were investigated in older adults before and after the COVID-19 pandemic.

methodsOlder women (

resultsOlder women showed higher GS and TUG at POST than PRE and POST-TR but lower HG at POST-TR than PRE, whereas older men exhibited lower HG at POST and POST-TR than PRE. Both groups presented (1) lower IL-10 and IL-12p70 values in contrast to higher IL-6/IL-10 and IL-8/IL-10 ratios at POST than PRE; (2) higher IL-10 values and lower IL-8/IL-10 ratio at POST-TR than POST; (3) higher IL-12p70/IL-10 ratio at POST-TR than PRE and POST. Particularly, older women showed (4) lower IL-6 values at POST and POST-TR than PRE; (5) lower IL-8 and IL-10 values at POST-TR than POST; (6) and higher TNF-α/IL-10 and IFN-γ/IL-10 ratios at POST than PRE and POST-TR. Significant correlations between the variables were found in both groups. DISCUSSION: During the COVID-19 pandemic, detraining and resumption of exercise training promoted distinct alterations in physical capacity and inflammaging among older women and older men.

Indexed as

COVID-19CytokinesExerciseInflammationAgedAged, 80 and overAgingFemaleHumansMalePandemicsSARS-CoV-2Cytokinesagingcytokinesgait speedhandgripinflammagingolder peoplephysical exerciseTUGT

Identifiers

PMID39595692
PMCPMC11593455

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.