Evidence map›Paper›PMID 39595636›Full record

ArticleBiomolecules2024

Tumor-Colonizing

Lara C Avsharian, Suvithanandhini Loganathan, Nancy D Ebelt, Azadeh F Shalamzari, Itzel Rodarte Muñoz, Edwin R Manuel

Abstract read
In one paragraph

Article in Biomolecules, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Lara C AvsharianDepartment of Immuno-Oncology, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA.ORCID 0009-0005-7287-8650
Suvithanandhini LoganathanDepartment of Immuno-Oncology, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA.ORCID 0000-0003-2608-5092
Nancy D EbeltDepartment of Immuno-Oncology, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA.ORCID 0000-0002-1998-3719
Azadeh F ShalamzariIrell and Manella Graduate School of Biological Sciences, City of Hope, Duarte, CA 91010, USA.
Itzel Rodarte MuñozDepartment of Immuno-Oncology, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA.
Edwin R ManuelDepartment of Immuno-Oncology, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA.ORCID 0000-0002-4602-7060

Funding

Transgenic Mouse FacilityP30CA033572 · NCI · CITY OF HOPE/BECKMAN RESEARCH INSTITUTE · PI John Charles Williams · 1985 to 2026
$86.3M
Development of Microbial-Based Therapies to Suppress Macropinocytosis in Kras-Driven CancersR01CA272732 · NCI · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI Edwin Ramos Manuel · 2022 to 2026
$2.0M
Microbial- based targeting of major extracellular matrix components for improved therapy of pancreatic cancerR01CA266472 · NCI · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI MANUEL, EDWIN · 2022 to 2025
$1.8M
Modulating Intratumoral Immune Composition to Enhance ImmunotherapyR21CA293969 · NCI · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI MANUEL, EDWIN · 2024 to 2024
$458k
Utilizing Hybrid Antigen-Presenting Neutrophils to Prime WT1-Specific Immune Responses as Therapy for Acute LeukemiaR21CA256593 · NCI · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI MANUEL, EDWIN · 2022 to 2023
$448k
NCI NIH HHS P30 CA033572NCI NIH HHS P30CA033572NCI NIH HHS R01 CA266472NCI NIH HHS R01CA266472, R01CA272732, R21CA256593, R21CA293969NCI NIH HHS R01 CA272732NCI NIH HHS R21 CA256593NCI NIH HHS R21 CA293969
6 · The paper itself

Abstract

Desmoplasia is a hallmark feature of pancreatic ductal adenocarcinoma (PDAC) that contributes significantly to treatment resistance. Approaches to enhance drug delivery into fibrotic PDAC tumors continue to be an important unmet need. In this study, we have engineered a tumor-colonizing

Indexed as

Carcinoma, Pancreatic DuctalCollagenasesDeoxycytidineEscherichia coliGemcitabineHyaluronoglucosaminidasePancreatic NeoplasmsAnimalsCell Line, TumorHumansHyaluronic AcidMiceCollagenasesDeoxycytidineGemcitabineHyaluronic AcidHyaluronoglucosaminidasebacterial vectorcollagencollagenasedesmoplasiafibrosishyaluronanhyaluronidasepancreatic ductal adenocarcinomaresistance

Identifiers

PMID39595636
PMCPMC11591662

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.