Evidence map›Paper›PMID 39595631›Full record

ArticleBiomolecules2024

Chaga Mushroom Triterpenoids Inhibit Dihydrofolate Reductase and Act Synergistically with Conventional Therapies in Breast Cancer.

Junbiao Wang, Daniela Beghelli, Augusto Amici, Stefania Sut, Stefano Dall'Acqua, Giulio Lupidi, Diego Dal Ben, Onelia Bistoni, Daniele Tomassoni, Barbara Belletti and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Green Extraction and Liposomal Encapsulation ofMolecules (Basel, Switzerland) · 2026
    Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Junbiao WangSchool of Biosciences and Veterinary Medicine, Via Gentile III da Varano, University of Camerino, 62032 Camerino, Italy.ORCID 0000-0001-8695-323X
Daniela BeghelliSchool of Biosciences and Veterinary Medicine, Via Gentile III da Varano, University of Camerino, 62032 Camerino, Italy.ORCID 0000-0002-4935-7874
Augusto AmiciSchool of Biosciences and Veterinary Medicine, Via Gentile III da Varano, University of Camerino, 62032 Camerino, Italy.
Stefania SutDAFNAE Dipartimento di Agronomia, Animali, Alimenti, Risorse Naturali e Ambiente, University of Padova, 35020 Legnaro, Italy.
Stefano Dall'AcquaDSF Department of Pharmaceutical and Pharmacological Sciences, University of Padova, 35121 Padova, Italy.ORCID 0000-0001-8264-6953
Giulio LupidiSchool of Pharmacy, University of Camerino, 62032 Camerino, Italy.
Diego Dal BenSchool of Pharmacy-Chemistry Interdisciplinary Project (CHIP), University of Camerino, 62032 Camerino, Italy.ORCID 0000-0002-6616-6885
Onelia BistoniRheumatology Unit, Department of Medicine and Surgery, University of Perugia, 06123 Perugia, Italy.
Daniele TomassoniSchool of Biosciences and Veterinary Medicine, Via Gentile III da Varano, University of Camerino, 62032 Camerino, Italy.ORCID 0000-0001-9062-3305
Barbara BellettiMolecular Oncology Unit, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, National Cancer Institute, 33081 Aviano, Italy.ORCID 0000-0003-2249-0285
Sanaa MusaNatural Compounds and Organic Synthesis, Migal-Galilee Research Institute, Kiryat Shmona 11016, Israel.ORCID 0000-0002-0014-9038
Jamal MahajnaNatural Compounds and Organic Synthesis, Migal-Galilee Research Institute, Kiryat Shmona 11016, Israel.ORCID 0000-0003-2218-2039
Stefania PucciarelliSchool of Biosciences and Veterinary Medicine, Via Gentile III da Varano, University of Camerino, 62032 Camerino, Italy.ORCID 0000-0003-2137-5517
Cristina MarchiniSchool of Biosciences and Veterinary Medicine, Via Gentile III da Varano, University of Camerino, 62032 Camerino, Italy.ORCID 0000-0001-7692-8428

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Breast NeoplasmsTetrahydrofolate DehydrogenaseTriterpenesAgaricalesAntineoplastic AgentsCell CycleCell Line, TumorCell ProliferationCell SurvivalDrug SynergismFemaleFolic Acid AntagonistsHumansInonotusAntineoplastic AgentsFolic Acid AntagonistsTetrahydrofolate DehydrogenaseTriterpenesbreast cancercell cycle regulationChaga mushroom (Inonotus obliquus)DHFRtriterpenoids

Identifiers

PMID39595631
PMCPMC11591880

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.