Evidence map›Paper›PMID 39595618›Full record

ReviewBiomolecules2024

Action-At-A-Distance in DNA Mismatch Repair: Mechanistic Insights and Models for How DNA and Repair Proteins Facilitate Long-Range Communication.

Bryce W Collingwood, Scott J Witte, Carol M Manhart

Abstract readReview
In one paragraph

Review in Biomolecules, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Bryce W CollingwoodDepartment of Chemistry, Temple University, Philadelphia, PA 19122, USA.
Scott J WitteDepartment of Chemistry, Temple University, Philadelphia, PA 19122, USA.
Carol M ManhartDepartment of Chemistry, Temple University, Philadelphia, PA 19122, USA.ORCID 0000-0002-0201-4348

Funding

Molecular Mechanisms Of Modular Nuclease DomainsR35GM142651 · NIGMS · TEMPLE UNIV OF THE COMMONWEALTH · PI MANHART, CAROL M · 2021 to 2025
$1.8M
NIGMS NIH HHS R35 GM142651NIH HHS R35GM142651
6 · The paper itself

Abstract

Many DNA metabolic pathways, including DNA repair, require the transmission of signals across long stretches of DNA or between DNA molecules. Solutions to this signaling challenge involve various mechanisms: protein factors can travel between these sites, loop DNA between sites, or form oligomers that bridge the spatial gaps. This review provides an overview of how these paradigms have been used to explain DNA mismatch repair, which involves several steps that require action-at-a-distance. Here, we describe these models in detail and how current data fit into these descriptions. We also outline regulation steps that remain unanswered in how the action is communicated across long distances along a DNA contour in DNA mismatch repair.

Indexed as

DNADNA Mismatch RepairAnimalsHumansDNADNA mismatch repairDNA polymerase δDNA repairEXO1MutLMutS

Identifiers

PMID39595618
PMCPMC11592386

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.