Evidence map›Paper›PMID 39595591›Full record

ArticleBiomolecules2024

Impact of Overnight Storage of Human Atrial Myocytes on Intracellular Calcium Homeostasis and Electrophysiological Utility.

Cristina Aceituno, David Revuelta, Verónica Jiménez-Sábado, Antonino Ginel, Cristina E Molina, Leif Hove-Madsen

Abstract read
In one paragraph

Article in Biomolecules, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Cristina AceitunoCardiac Rhythm and Contraction Group, Biomedical Research Institute of Barcelona (IIBB-CSIC), Rosselló 161, 08036 Barcelona, Spain.
David RevueltaInstitute of Experimental Cardiovascular Research, University Medical Center Hamburg Eppendorf (UKE), Martinistrasse 52, W23, 20246 Hamburg, Germany.
Verónica Jiménez-SábadoCardiac Rhythm and Contraction Group, Institut de Recerca Sant Pau, St. Antoni Mª Claret 167, 08025 Barcelona, Spain.ORCID 0000-0001-7720-988X
Antonino GinelCardiac Surgery Department and IR Sant Pau, St. Antoni Mª Claret 167, 08025 Barcelona, Spain.ORCID 0000-0002-8820-7545
Cristina E MolinaInstitute of Experimental Cardiovascular Research, University Medical Center Hamburg Eppendorf (UKE), Martinistrasse 52, W23, 20246 Hamburg, Germany.ORCID 0000-0003-3094-1568
Leif Hove-MadsenCardiac Rhythm and Contraction Group, Biomedical Research Institute of Barcelona (IIBB-CSIC), Rosselló 161, 08036 Barcelona, Spain.ORCID 0000-0001-5493-3998

Funding

Deutsche Forschungsgemeinschaft ES 569/2-2Deutsche Forschungsgemeinschaft ES 569/3-1Ministerio de Ciencia, Innovación y Universidades PID2020-116927RB-C21Ministerio de Ciencia, Innovación y Universidades PID2023-152610OB-C21
6 · The paper itself

Abstract

Human atrial myocytes afford an attractive experimental model to investigate mechanisms underlying electrophysiological alterations in cardiovascular disease. However, this model presents limitations, such as the availability of human atrial tissue and a variable yield of myocytes isolation. Therefore, we aimed to determine whether overnight storage can increase the time window where the electrophysiological properties of human atrial myocytes can be determined. To address this issue, human atrial myocytes isolated from patients undergoing cardiac surgery were used for patch-clamp experiments on the day of cell isolation (Day 1) and the following day (Day 2). The shape of the current-voltage (I-V) relationship for the calcium current (I

Indexed as

CalciumHeart AtriaHomeostasisMyocytes, CardiacAction PotentialsAgedElectrophysiological PhenomenaFemaleHumansMaleMiddle AgedPatch-Clamp TechniquesSarcoplasmic ReticulumCalciumbeat-to-beat responsecalcium currentscalcium homeostasishuman atrial myocytepatch-clamp techniquesarcoplasmic reticulum

Identifiers

PMID39595591
PMCPMC11591567

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.