Evidence map›Paper›PMID 39595574›Full record

ArticleBiomolecules2024

Molecular Profiling of Mouse Models of Loss or Gain of Function of the KCNT1 (Slack) Potassium Channel and Antisense Oligonucleotide Treatment.

Fangxu Sun, Huafeng Wang, Jing Wu, Imran H Quraishi, Yalan Zhang, Maysam Pedram, Benbo Gao, Elizabeth A Jonas, Viet Nguyen, Sijia Wu and 3 more

Abstract read
In one paragraph

Article in Biomolecules, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Fangxu SunBiogen Inc., Cambridge, MA 02142, USA.
Huafeng WangDepartment of Pharmacology, Yale University School of Medicine, New Haven, CT 06520, USA.
Jing WuDepartment of Pharmacology, Yale University School of Medicine, New Haven, CT 06520, USA.
Imran H QuraishiDepartment of Neurology, Yale University School of Medicine, New Haven, CT 06520, USA.ORCID 0000-0003-2859-7446
Yalan ZhangDepartment of Pharmacology, Yale University School of Medicine, New Haven, CT 06520, USA.
Maysam PedramDepartment of Pharmacology, Yale University School of Medicine, New Haven, CT 06520, USA.
Benbo GaoBiogen Inc., Cambridge, MA 02142, USA.
Elizabeth A JonasDepartment of Internal Medicine, Yale School of Medicine, New Haven, CT 06520, USA.
Viet NguyenBiogen Inc., Cambridge, MA 02142, USA.ORCID 0000-0001-6867-6929
Sijia WuBiogen Inc., Cambridge, MA 02142, USA.ORCID 0000-0001-5729-3973
Omar S MabroukBiogen Inc., Cambridge, MA 02142, USA.
Paymaan Jafar-NejadIonis Pharmaceuticals Inc., Carlsbad, CA 92010, USA.ORCID 0000-0001-5176-739X
Leonard K KaczmarekDepartment of Pharmacology, Yale University School of Medicine, New Haven, CT 06520, USA.ORCID 0000-0001-5128-6326

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Cellular Regulation of Sodium-activated Potassium ChannelsR01NS102239 · NINDS · YALE UNIVERSITY · PI LEONARD K KACZMAREK · 2018 to 2026
$3.5M
NCATS NIH HHS UL1 TR001863NIH HHS NS102239NINDS NIH HHS R01 NS102239
6 · The paper itself

Abstract

The potassium sodium-activated channel subtype T member 1 (

Indexed as

Disease Models, AnimalMice, KnockoutOligonucleotides, AntisenseAnimalsCerebral CortexEpilepsyGain of Function MutationHumansMaleMiceMitochondriaNerve Tissue ProteinsPotassium ChannelsProteomicsNerve Tissue ProteinsOligonucleotides, AntisensePotassium ChannelsEIMFSepilepsyintellectual disabilityKCNT1KNa1.1mitochondriaproteomicsslack

Identifiers

PMID39595574
PMCPMC11591899

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.