Evidence map›Paper›PMID 39595563›Full record

ArticleBiomolecules2024

Effect of Integrin Blockade on Experimental Spondyloarthritis.

Enoch Yau, Melissa Lim, Zoya Qaiyum, Shaghayegh Foroozan Boroojeni, Michael Tang, Addison Pacheco, Fataneh Tavasolian, Robert D Inman

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. The gut-joint axis in juvenile idiopathic arthritis.Arthritis research & therapy · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Enoch YauSchroeder Arthritis Institute, Toronto Western Hospital, University Health Network, Toronto, ON M5G 2C4, Canada.
Melissa LimSchroeder Arthritis Institute, Toronto Western Hospital, University Health Network, Toronto, ON M5G 2C4, Canada.
Zoya QaiyumSchroeder Arthritis Institute, Toronto Western Hospital, University Health Network, Toronto, ON M5G 2C4, Canada.
Shaghayegh Foroozan BoroojeniSchroeder Arthritis Institute, Toronto Western Hospital, University Health Network, Toronto, ON M5G 2C4, Canada.
Michael TangSchroeder Arthritis Institute, Toronto Western Hospital, University Health Network, Toronto, ON M5G 2C4, Canada.
Addison PachecoSchroeder Arthritis Institute, Toronto Western Hospital, University Health Network, Toronto, ON M5G 2C4, Canada.ORCID 0000-0003-4684-2775
Fataneh TavasolianSchroeder Arthritis Institute, Toronto Western Hospital, University Health Network, Toronto, ON M5G 2C4, Canada.
Robert D InmanSchroeder Arthritis Institute, Toronto Western Hospital, University Health Network, Toronto, ON M5G 2C4, Canada.

Funding

CIHR 399454
6 · The paper itself

Abstract

Spondyloarthritis (SpA) describes a group of diseases characterized by chronic inflammation in the spine and peripheral joints. While pathogenesis is still unclear, proinflammatory gut-derived immune cells have been identified in the joints of SpA patients. We previously identified an enriched population of integrin-expressing cells in the joints of SpA patients. Entry of gut-derived cells into joints may be mediated by these integrins. In the current study, we used the SKG murine model of SpA to study the impact of integrin blockade. Mice were injected with antibodies against the integrin α4β7 or the β7 monomer twice a week. Treatment with antibodies against α4β7 reduced disease severity in curdlan-injected SKG mice, with disease scores being comparable between treatment initiation times. Targeting the β7 monomer led to reduced arthritis severity compared to targeting the α4β7 dimer. Treatment with antibodies against α4β7 or β7 decreased expression of these integrins in CD4+ T cells, with the frequency of αE+β7+ T cells in the spleen and lymph nodes correlating with disease severity. In summary, we showed that integrin blockade showed potential for ameliorating disease in a murine model of SpA, lending support for further studies testing integrin blockade in SpA.

Indexed as

Disease Models, AnimalIntegrinsSpondylarthritisAnimalsbeta-GlucansCD4-Positive T-LymphocytesFemaleIntegrin beta ChainsMicebeta-Glucanscurdlanintegrin alpha4beta7integrin beta7Integrin beta ChainsIntegrinsbiologicsintegrinsSKGspondyloarthritis

Identifiers

PMID39595563
PMCPMC11591768

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.