Evidence map›Paper›PMID 39595528›Full record

ReviewBiomolecules2024

Psoriasis: The Versatility of Mesenchymal Stem Cell and Exosome Therapies.

Aidar Dairov, Aliya Sekenova, Symbat Alimbek, Assiya Nurkina, Miras Shakhatbayev, Venera Kumasheva, Sandugash Kuanysh, Zhansaya Adish, Assel Issabekova, Vyacheslav Ogay

Abstract readReview
In one paragraph

Review in Biomolecules, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Aidar DairovStem Cell Laboratory, National Center for Biotechnology, Astana 010000, Kazakhstan.ORCID 0000-0003-1529-8471
Aliya SekenovaStem Cell Laboratory, National Center for Biotechnology, Astana 010000, Kazakhstan.ORCID 0000-0002-0382-1731
Symbat AlimbekStem Cell Laboratory, National Center for Biotechnology, Astana 010000, Kazakhstan.
Assiya NurkinaStem Cell Laboratory, National Center for Biotechnology, Astana 010000, Kazakhstan.
Miras ShakhatbayevStem Cell Laboratory, National Center for Biotechnology, Astana 010000, Kazakhstan.ORCID 0009-0000-7486-5267
Venera KumashevaStem Cell Laboratory, National Center for Biotechnology, Astana 010000, Kazakhstan.
Sandugash KuanyshObstetrics and Gynecology, Astana Medical University, Astana 010000, Kazakhstan.
Zhansaya AdishLaboratory of Immunochemistry and Immunobiotechnology, National Center for Biotechnology, Astana 010000, Kazakhstan.ORCID 0000-0001-9527-8774
Assel IssabekovaStem Cell Laboratory, National Center for Biotechnology, Astana 010000, Kazakhstan.ORCID 0000-0002-8844-2510
Vyacheslav OgayStem Cell Laboratory, National Center for Biotechnology, Astana 010000, Kazakhstan.ORCID 0000-0001-5029-5255

Funding

Ministry of Education and Science of the Republic of Kazakhstan AP13068269 "Study of therapeutic effect of exosomes derived from cytokine-preconditioned mesenchymal stem cells in mouse model of psoriasis"
6 · The paper itself

Abstract

Mesenchymal stem cells (MSCs) are multilineage differentiating stromal cells with extensive immunomodulatory and anti-inflammatory properties. MSC-based therapy is widely used in the treatment of various pathologies, including bone and cartilage diseases, cardiac ischemia, diabetes, and neurological disorders. Along with MSCs, it is promising to study the therapeutic properties of exosomes derived from MSCs (MSC-Exo). A number of studies report that the therapeutic properties of MSC-Exo are superior to those of MSCs. In particular, MSC-Exo are used for tissue regeneration in various diseases, such as healing of skin wounds, cancer, coronary heart disease, lung injury, liver fibrosis, and neurological, autoimmune, and inflammatory diseases. In this regard, it is not surprising that the scientific community is interested in studying the therapeutic properties of MSCs and MSC-Exo in the treatment of psoriasis. This review summarizes the recent advancements from preclinical and clinical studies of MSCs and MSC-Exo in the treatment of psoriasis, and it also discusses their mechanisms of therapeutic action involved in the treatment of this disease.

Indexed as

ExosomesMesenchymal Stem CellsMesenchymal Stem Cell TransplantationPsoriasisAnimalsHumanscell therapyclinical studyimmunomodulationin vitroin vivomesenchymal stem cellmesenchymal-stem-cell-derived exosomepreconditioningpsoriasis

Identifiers

PMID39595528
PMCPMC11591958

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.