ArticleHealthcare (Basel, Switzerland)2024
Effect of Genotype on the Response to Diet in Cardiovascular Disease-A Scoping Review.
Article in Healthcare (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- A nutrient wide association study of cardiovascular disease prevalence in older adults from NHANES 2007 to 2018.Scientific reports · 2025Article
- ANGPTL3 and residual atherosclerotic risk: from lipid metabolism to therapeutic targeting.Frontiers in endocrinology · 2025Review
- Redefining Protein Quality: Integrating Health Outcomes and Environmental Impacts in the Plant-Animal Protein Debate.Foods (Basel, Switzerland) · 2024Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
objectivesNutrigenetics investigates the role of genetic variants that contribute to the inter-individual variation in response to food intake. Risk factors for cardiovascular disease (CVD) are influenced by the complex interplay of genetic and environmental factors, including the diet. The aim of this scoping review is to analyze the literature on the effect of genotypes on the response to dietary interventions for the treatment of CVD risk factors.
methodsA literature search was conducted in MEDLINE to identify published articles fulfilling the inclusion criteria. Studies published in English between 2014 and 2024 were selected. Data were extracted according to the population, intervention, comparison, and outcome (PICO) format.
resultsForty-eight studies met the inclusion criteria. The studies differed in design, intervention characteristics, tested genotypes, and ancestry. The most frequently analyzed variants were single-nucleotide polymorphisms (SNPs) in genes associated with lipid metabolism, inflammation, and energy balance, among others. The interventions tested the effects of different dietary patterns, diets modified in macronutrient content and types of fat, natural and processed foods, nutraceuticals, and nutrient supplements. Common
conclusionsGene-diet interactions are observed in multiple dietary interventions. Replication of findings of nutrigenetic studies is required across different populations. The response to dietary treatments modifies CVD-related risk factors and shows variation associated with genotypes.
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Registered trials
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