ArticleAnimals : an open access journal from MDPI2024
Comparison Between Medetomidine and a Medetomidine-Vatinoxan Combination on Cardiorespiratory Variables in Dogs Undergoing Ovariectomy Anesthetized with Butorphanol, Propofol and Sevoflurane or Desflurane.
Article in Animals : an open access journal from MDPI, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Evaluating the Physiological and Sedation Parameters of Zenalpha (Medetomidine and Vatinoxan Hydrochloride Injection) in Combination with Ketamine in Rhesus Macaques (Macaca mulatta).Journal of the American Association for Laboratory Animal Science : JAALAS · 2026Article
- Medetomidine-vatinoxan-methadone and acepromazine-methadone: comparison of sedative and cardiovascular properties as a preanaesthetic medication in healthy dogs.Acta veterinaria Scandinavica · 2025Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
The aim of this study was to compare the effects of a medetomidine-vatinoxan combination versus medetomidine alone on heart rate (HR) and mean arterial pressure (MAP) in a short-term surgery in dogs. Four groups of 10 dogs were administered as follows: medetomidine and sevoflurane; medetomidine and desflurane; medetomidine-vatinoxan and sevoflurane; and medetomidine-vatinoxan and desflurane. After administration, the increase in MAP soon stopped at 102-104 mmHg in the two groups administered medetomidine-vatinoxan, compared with significantly higher values of 143-126 mmHg achieved in the two groups administered medetomidine alone. The lowest MAPs in the two medetomidine-vatinoxan groups were 46-50 mmHg, while in the medetomidine groups, they were 58-79 mmHg. From 3 min onwards after administration, in the medetomidine-vatinoxan treatments, HR remained at values very close to those of pre-administration, between 83 and 118 beats min
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.