Evidence map›Paper›PMID 39595370›Full record

ArticleAnimals : an open access journal from MDPI2024

From Gene to Protein: Unraveling the Reproductive Blueprint of Male Grey Squirrels via Nerve Growth Factor (NGF) and Cognate Receptors.

Francesca Mercati, Gabriella Guelfi, Antonello Bufalari, Cecilia Dall'Aglio, Chiara Suvieri, Paolo Cocci, Francesco Alessandro Palermo, Polina Anipchenko, Camilla Capaccia, Beniamino Cenci-Goga and 2 more

Abstract read
In one paragraph

Article in Animals : an open access journal from MDPI, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Francesca MercatiDepartment of Veterinary Medicine, University of Perugia, Via San Costanzo 4, 06126 Perugia, Italy.ORCID 0000-0002-8799-1200
Gabriella GuelfiDepartment of Veterinary Medicine, University of Perugia, Via San Costanzo 4, 06126 Perugia, Italy.ORCID 0000-0003-3695-9275
Antonello BufalariDepartment of Veterinary Medicine, University of Perugia, Via San Costanzo 4, 06126 Perugia, Italy.ORCID 0000-0001-5073-6540
Cecilia Dall'AglioDepartment of Veterinary Medicine, University of Perugia, Via San Costanzo 4, 06126 Perugia, Italy.ORCID 0000-0001-6451-3751
Chiara SuvieriDepartment of Medicine and Surgery, University of Perugia, Piazzale Settimio Gambuli, 1, 06129 Perugia, Italy.ORCID 0000-0002-0634-0386
Paolo CocciSchool of Bioscience and Veterinary Medicine, University of Camerino, Via Gentile III Da Varano, 62032 Camerino, Italy.
Francesco Alessandro PalermoSchool of Bioscience and Veterinary Medicine, University of Camerino, Via Gentile III Da Varano, 62032 Camerino, Italy.
Polina AnipchenkoDepartment of Veterinary Medicine, University of Perugia, Via San Costanzo 4, 06126 Perugia, Italy.ORCID 0000-0001-8871-550X
Camilla CapacciaDepartment of Veterinary Medicine, University of Perugia, Via San Costanzo 4, 06126 Perugia, Italy.ORCID 0000-0002-1040-6245
Beniamino Cenci-GogaDepartment of Veterinary Medicine, University of Perugia, Via San Costanzo 4, 06126 Perugia, Italy.ORCID 0000-0002-3993-6258
Massimo ZeraniDepartment of Veterinary Medicine, University of Perugia, Via San Costanzo 4, 06126 Perugia, Italy.
Margherita MaranesiDepartment of Veterinary Medicine, University of Perugia, Via San Costanzo 4, 06126 Perugia, Italy.ORCID 0000-0002-1727-4118

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The grey squirrel, an invasive species, threatens the Eurasian red squirrel's conservation, particularly in Umbria, Italy. Understanding its reproductive biology is essential to limiting its reproductive success. This study investigates the NGF system and its receptors (NTRK1 and p75NTR) in the testes of male grey squirrels, following prior research on female reproductive biology. NGF plays a role in testicular morphogenesis and spermiogenesis in animals and humans. As part of the LIFE Project U-SAVEREDS, eighteen squirrels were captured and classified into three morphotypes (immature, pubertal, and active spermatogenesis). NGF and its receptors were analyzed using real-time PCR, western blotting, immunohistochemistry, and plasma levels measured via ELISA. NGF qPCR expression levels were significantly higher during puberty compared to the immature and spermatogenesis stages (

Indexed as

grey squirrelNGFNTRK1P75NTRreproductive phasestestis

Identifiers

PMID39595370
PMCPMC11591181

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.