Evidence map›Paper›PMID 39595222›Full record

ArticleAnimals : an open access journal from MDPI2024

Immunohistochemical Investigation of Cyclooxygenase-2 Expression in Rabbit Uterine Adenocarcinoma and the Potential Use of COX-2 Inhibitors in Cancer Therapy.

Emanuela Vaccaro, Luigi Navas, Martina Ercolano, Giuseppe Piegari, Evaristo Di Napoli, Serenella Papparella, Donato Inverso, Barbara Brunetti, Orlando Paciello, Valeria Russo

Abstract read
In one paragraph

Article in Animals : an open access journal from MDPI, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Emanuela VaccaroDepartment of Veterinary Medicine and Animal Productions, University of Naples Federico II, 80137 Naples, Italy.ORCID 0009-0006-0380-0005
Luigi NavasDepartment of Veterinary Medicine and Animal Productions, University of Naples Federico II, 80137 Naples, Italy.ORCID 0000-0002-1851-5016
Martina ErcolanoDepartment of Veterinary Medicine and Animal Productions, University of Naples Federico II, 80137 Naples, Italy.
Giuseppe PiegariDepartment of Veterinary Medicine and Animal Productions, University of Naples Federico II, 80137 Naples, Italy.ORCID 0000-0002-1637-4205
Evaristo Di NapoliDepartment of Veterinary Medicine and Animal Productions, University of Naples Federico II, 80137 Naples, Italy.
Serenella PapparellaDepartment of Veterinary Medicine and Animal Productions, University of Naples Federico II, 80137 Naples, Italy.
Donato InversoVascular Pathobiology Unit, San Raffaele Scientific Institute, 20132 Milan, Italy.
Barbara BrunettiDepartment of Veterinary Medical Sciences, University of Bologna, Ozzano dell'Emilia, 40126 Bologna, Italy.ORCID 0000-0002-2694-905X
Orlando PacielloDepartment of Veterinary Medicine and Animal Productions, University of Naples Federico II, 80137 Naples, Italy.ORCID 0000-0003-3091-0905
Valeria RussoDepartment of Veterinary Medicine and Animal Productions, University of Naples Federico II, 80137 Naples, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cyclooxygenase-2 (COX-2) is overexpressed in many human and animal cancers. Selective COX-2 inhibitors have shown antitumoral effects in tumors with a high expression of COX-2. This study evaluates (1) the expression of COX-2 in rabbit uterine adenocarcinomas, (2) the correlation between immunophenotypic expression and histopathological changes, and (3) the post-surgery response to therapy with COX-2 inhibitors. Forty rabbit uteri were divided into three groups:

Indexed as

COX-2endometrial adenocarcinomaimmunohistochemistrymeloxicamrabbit

Identifiers

PMID39595222
PMCPMC11590897

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.