Evidence map›Paper›PMID 39595184›Full record

ArticleBiomedicines2024

Short-Cycle Therapy with Bictegravir/Emtricitabine/Tenofovir Alafenamide in a Small Cohort of Virally Suppressed People Living with HIV: A Long-Term Follow-Up.

Massimiliano Lanzafame, Emanuela Lattuada, Andrea Delama, Giovanni Mori, Sandro Vento

Abstract read
In one paragraph

Article in Biomedicines, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Massimiliano LanzafameUnit of Infectious Diseases, Santa Chiara Hospital, Azienda Provinciale per i Servizi Sanitari, 38122 Trento, Italy.ORCID 0000-0002-4674-4772
Emanuela LattuadaUnit of Infectious Diseases, Santa Chiara Hospital, Azienda Provinciale per i Servizi Sanitari, 38122 Trento, Italy.
Andrea DelamaUnit of Infectious Diseases, Santa Chiara Hospital, Azienda Provinciale per i Servizi Sanitari, 38122 Trento, Italy.
Giovanni MoriUnit of Infectious Diseases, Santa Chiara Hospital, Azienda Provinciale per i Servizi Sanitari, 38122 Trento, Italy.ORCID 0000-0003-0399-2220
Sandro VentoFaculty of Medicine, University of Puthisastra, Phnom Penh 12211, Cambodia.ORCID 0000-0003-0084-4062

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAntiretroviral triple therapy has considerably reduced morbidity and mortality in people living with HIV and is the standard-of-care treatment. However, it is lifelong and linked to long-term side effects and adherence problems.

methodsHere, we report long-term virological and immunological outcome in 12 virally suppressed people on short-cycle therapy with bictegravir/emtricitabine/tenofovir alafenamide administered five days a week (Monday to Friday).

resultsAll patients, after a long term follow-up, were virally suppressed Conclusions: In the wait for new long-acting antiretroviral drugs and new antiretroviral formulations, short-cycle therapy has proven to be a safe and effective alternative to the standard daily antiretroviral regimen for individuals living with HIV who are virologically suppressed.

Indexed as

antiretroviral treatmentbictegravirHIVshort-cycle therapyvirologically suppressed people

Identifiers

PMID39595184
PMCPMC11592082

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.