Evidence map›Paper›PMID 39595048›Full record

ArticleBiomedicines2024

ZNF671 Silencing Affects Signaling Pathways in Head and Neck Cancer via Activation of Oncogenic Non-Coding RNAs.

Kendra Smith, Rufa'i Umar Zubair, Richard V Smith, Stelby Augustine, Nicholas F Schlecht, Thomas J Ow, Michael B Prystowsky, Thomas J Belbin

Abstract read
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In one paragraph

Article in Biomedicines, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Kendra SmithDivision of Biomedical Sciences, Faculty of Medicine, Memorial University of Newfoundland, St. John's, NL A1B 3V6, Canada.
Rufa'i Umar ZubairDivision of Biomedical Sciences, Faculty of Medicine, Memorial University of Newfoundland, St. John's, NL A1B 3V6, Canada.
Richard V SmithDepartment of Otorhinolaryngology-Head and Neck Surgery, Montefiore Med Center, 3400 Bainbridge Ave., Bronx, NY 10467, USA.
Stelby AugustineDepartment of Otorhinolaryngology-Head and Neck Surgery, Montefiore Med Center, 3400 Bainbridge Ave., Bronx, NY 10467, USA.
Nicholas F SchlechtDepartment of Cancer Prevention and Control, Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, Buffalo, NY 14263, USA.ORCID 0000-0003-2482-244X
Thomas J OwDepartment of Otorhinolaryngology-Head and Neck Surgery, Montefiore Med Center, 3400 Bainbridge Ave., Bronx, NY 10467, USA.
Michael B PrystowskyDepartment of Pathology, Albert Einstein College of Medicine, 1300 Morris Park Ave., Bronx, NY 10461, USA.ORCID 0000-0002-9548-6917
Thomas J BelbinDivision of Biomedical Sciences, Faculty of Medicine, Memorial University of Newfoundland, St. John's, NL A1B 3V6, Canada.ORCID 0000-0001-6867-654X

Funding

CIHR 20172025GlaxoSmithKline (GSK) XGS-154082
6 · The paper itself

Abstract

backgroundNovel ZNF genes, such as ZNF671, that are located on chromosome 19q13 are known to be hypermethylated at a high frequency in HNSCC as well as in other epithelial solid tumors. Their function is largely unknown.

resultsHere, we show that ZNF671 is epigenetically silenced in HNSCC primary tumors compared to matched adjacent normal tissue. Moreover, low expression of ZNF671 is significantly associated with decreased survival in HNSCC patients. Over-expression of ZNF671 in UM-SCC-1 oral cancer cells resulted in a significant reduction in tumor cell mobility and invasion compared to the empty-vector control cells. Transcriptomic analysis showed that ZNF671 re-expression resulted in a significant decrease in the expression of a major oncogenic long non-coding RNA LINC00665.

conclusionsTogether, these results suggest that epigenetic silencing of ZNF671 may activate multiple oncogenic signaling pathways via the resulting up-regulation of LINC00665.

Indexed as

carcinomaLINC00665oral cavitysquamousZNF671

Identifiers

PMID39595048
PMCPMC11592198

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.