Evidence map›Paper›PMID 39594804›Full record

ArticleCancers2024

Characterization of Breast Cancer Intra-Tumor Heterogeneity Using Artificial Intelligence.

Ayat G Lashen, Noorul Wahab, Michael Toss, Islam Miligy, Suzan Ghanaam, Shorouk Makhlouf, Nehal Atallah, Asmaa Ibrahim, Mostafa Jahanifar, Wenqi Lu and 10 more

Abstract read
In one paragraph

Article in Cancers, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Leveraging AI for cell biology discovery.Biochemical Society transactions · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Ayat G LashenBreast Cancer Research Unit, University of Nottingham, Nottingham NG7 2RD, UK.
Noorul WahabDepartment of Computer Science, University of Warwick, Coventry CV4 7AL, UK.
Michael TossBreast Cancer Research Unit, University of Nottingham, Nottingham NG7 2RD, UK.
Islam MiligyBreast Cancer Research Unit, University of Nottingham, Nottingham NG7 2RD, UK.
Suzan GhanaamBreast Cancer Research Unit, University of Nottingham, Nottingham NG7 2RD, UK.ORCID 0000-0003-4171-2605
Shorouk MakhloufBreast Cancer Research Unit, University of Nottingham, Nottingham NG7 2RD, UK.
Nehal AtallahBreast Cancer Research Unit, University of Nottingham, Nottingham NG7 2RD, UK.
Asmaa IbrahimBreast Cancer Research Unit, University of Nottingham, Nottingham NG7 2RD, UK.
Mostafa JahanifarDepartment of Computer Science, University of Warwick, Coventry CV4 7AL, UK.
Wenqi LuDepartment of Computer Science, University of Warwick, Coventry CV4 7AL, UK.
Simon GrahamDepartment of Computer Science, University of Warwick, Coventry CV4 7AL, UK.
Mohsin BilalDepartment of Computer Science, University of Warwick, Coventry CV4 7AL, UK.ORCID 0000-0001-8632-2729
Abhir BhaleraoDepartment of Computer Science, University of Warwick, Coventry CV4 7AL, UK.ORCID 0000-0001-8830-329X
Nigel P MonganSchool of Veterinary Medicine and Sciences, University of Nottingham, Nottingham LE12 5RD, UK.
Fayyaz MinhasDepartment of Computer Science, University of Warwick, Coventry CV4 7AL, UK.
Shan E Ahmed RazaDepartment of Computer Science, University of Warwick, Coventry CV4 7AL, UK.
Elena ProvenzanoDepartment of Pathology, Cambridge Biomedical Research Centre, Cambridge University Hospitals, Cambridge CB2 0QQ, UK.
David SneadDepartment of Computer Science, University of Warwick, Coventry CV4 7AL, UK.
Nasir RajpootDepartment of Computer Science, University of Warwick, Coventry CV4 7AL, UK.ORCID 0000-0002-4706-1308
Emad A RakhaBreast Cancer Research Unit, University of Nottingham, Nottingham NG7 2RD, UK.ORCID 0000-0002-5009-5525

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intra-tumor heterogeneity (ITH) is a fundamental characteristic of breast cancer (BC), influencing tumor progression, prognosis, and therapeutic responses. However, the complexity of ITH in BC makes its accurate characterization challenging. This study leverages deep learning (DL) techniques to comprehensively evaluate ITH in early-stage luminal BC and provide a nuanced understanding of its impact on tumor behavior and patient outcomes. A large cohort (

Indexed as

artificial intelligencebreast cancerintra-tumor heterogeneity

Identifiers

PMID39594804
PMCPMC11593220

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.