Evidence map›Paper›PMID 39594801›Full record

ArticleCancers2024

Black Soybean Seed Coat Extract Suppresses Gut Tumorigenesis by Augmenting the Production of Gut Microbiota-Derived Short-Chain Fatty Acids.

Yasuyuki Shimizu, Shunta Hirano, Mohammed Salah, Namiko Hoshi, Yoko Yamashita, Takeshi Fukumoto, Naritoshi Mukumoto, Ai Nakaoka, Takeaki Ishihara, Daisuke Miyawaki and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yasuyuki ShimizuDivision of Radiation Oncology, Graduate School of Medicine, Kobe University, Kobe 650-0017, Japan.
Shunta HiranoDivision of Radiation Oncology, Graduate School of Medicine, Kobe University, Kobe 650-0017, Japan.
Mohammed SalahDivision of Radiation Oncology, Graduate School of Medicine, Kobe University, Kobe 650-0017, Japan.
Namiko HoshiDivision of Gastroenterology, Department of Internal Medicine, Graduate School of Medicine, Kobe University, Kobe 650-0017, Japan.ORCID 0000-0003-2768-3991
Yoko YamashitaDepartment of Agrobioscience, Graduate School of Agricultural Science, Kobe University, Kobe 657-0013, Japan.
Takeshi FukumotoDivision of Dermatology, Department of Internal Related, Graduate School of Medicine, Kobe University, Kobe 650-0017, Japan.ORCID 0000-0003-0364-711X
Naritoshi MukumotoDivision of Radiation Oncology, Graduate School of Medicine, Kobe University, Kobe 650-0017, Japan.
Ai NakaokaDivision of Radiation Oncology, Graduate School of Medicine, Kobe University, Kobe 650-0017, Japan.
Takeaki IshiharaDivision of Radiation Oncology, Graduate School of Medicine, Kobe University, Kobe 650-0017, Japan.
Daisuke MiyawakiDivision of Radiation Oncology, Graduate School of Medicine, Kobe University, Kobe 650-0017, Japan.ORCID 0000-0003-2094-081X
Hitoshi AshidaDepartment of Agrobioscience, Graduate School of Agricultural Science, Kobe University, Kobe 657-0013, Japan.ORCID 0000-0003-3562-5601
Ryohei SasakiDivision of Radiation Oncology, Graduate School of Medicine, Kobe University, Kobe 650-0017, Japan.ORCID 0000-0002-4994-9386

Funding

Hyogo Science and Technology Association FY2020
6 · The paper itself

Abstract

backgroundProanthocyanidins (PACs) from black soybean seed coat have antioxidant and anti-tumorigenic properties. We investigated the anti-tumor properties and mechanisms of action of PACs on colorectal cancer (CRC).

methodsWe fed the APC

resultsThe number and size of intestinal polyps notably decreased in the PAC-fed mice. Compared with control mice, the PAC-fed mice showed lower expression of proliferation markers proliferating cell nuclear antigen and β catenin and a higher expression of the anti-inflammatory protein oligomeric mucus gel-forming. PAC supplementation increased the prevalence and concentrations of beneficial gut microbes and SCFAs, respectively.

conclusionsDiet supplemented with black soybean-derived PACs could prevent CRC development in mice through gut microbiome remodeling. Regions consuming black soybeans have low CRC incidence. Notably, the incidence of CRC, breast cancer, and liver cancer was significantly lower in Tamba than in the rest of Hyogo Prefecture or Japan. Future studies should delineate the mechanisms underlying the CRC-protective effects of PACs. Nevertheless, our results demonstrate the potential of including PACs in dietary recommendations for cancer prevention.

Indexed as

black soybeanscolorectal cancercolorectal preventionproanthocyanidinsTamba

Identifiers

PMID39594801
PMCPMC11592864

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.