Evidence map›Paper›PMID 39594797›Full record

ArticleCancers2024

Kallikrein-Related Peptidase 6 Contributes to Murine Intestinal Tumorigenesis Driven by a Mutant

Teodora G Georgieva, Dalila Darmoul, Hwudaurw Chen, Haiyan Cui, Photini F S Rice, Jennifer K Barton, David G Besselsen, Natalia A Ignatenko

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Teodora G GeorgievaGenetically Engineered Mouse Models Core, The University of Arizona Bio5 Institute, Tucson, AZ 85721-0240, USA.ORCID 0000-0002-8632-8714
Dalila DarmoulInstitut de Biologie Paris-Seine, Sorbonne Université, UMR CNRS 8256, INSERM ERL U1164, Biological Adaptation and Ageing, 75005 Paris, France.ORCID 0000-0002-1206-0655
Hwudaurw ChenDepartment of Cellular and Molecular Medicine, The University of Arizona Cancer Center, Tucson, AZ 85724-5024, USA.
Haiyan CuiDepartment of Cellular and Molecular Medicine, The University of Arizona Cancer Center, Tucson, AZ 85724-5024, USA.
Photini F S RiceDepartment of Biomedical Engineering, The University of Arizona, Tucson, AZ 85721-0240, USA.ORCID 0000-0001-7100-4023
Jennifer K BartonDepartment of Biomedical Engineering, The University of Arizona, Tucson, AZ 85721-0240, USA.
David G BesselsenUniversity Animal Care, The University of Arizona, Tucson, AZ 85721-0101, USA.
Natalia A IgnatenkoDepartment of Cellular and Molecular Medicine, The University of Arizona Cancer Center, Tucson, AZ 85724-5024, USA.ORCID 0000-0002-8096-1340

Funding

Dual-Modality System for Imaging Colon Cancer in MiceR01CA109385 · NCI · UNIVERSITY OF ARIZONA · PI BARTON, JENNIFER KEHLET · 2004 to 2013
$3.1M
Role of Kallikrein 6 expression and secretion in colon cancerR01CA157595 · NCI · UNIVERSITY OF ARIZONA · PI IGNATENKO, NATALIA A · 2012 to 2016
$1.7M
NCI NIH HHS R01 CA109385NCI NIH HHS R01 CA157595NIH HHS R01CA157595, R01CA109385
6 · The paper itself

Abstract

BACKGROUND/

objectivesThe objective of this study was to assess the role of a secreted serine protease, kallikrein-related peptidase 6 (KLK6), during colorectal tumorigenesis driven by a mutant METHODS AND

resultsThe presence of KLK6 protein in the adenomatous areas was confirmed by immunohistochemistry and optical coherence tomography/laser-induced fluorescence (OCT/LIF) imaging. To assess the contribution of the KLK6 expression on the

conclusionsThese findings demonstrate the oncogenic role of KLK6 in the mutant

Indexed as

APC mutationERK1/2 mitogen-activated protein kinasekallikrein-related peptidase 6KLK6 conditional knockout mousetransforming growth factor β2 isoformβ-catenin

Identifiers

PMID39594797
PMCPMC11592602

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.