Evidence map›Paper›PMID 39594780›Full record

ReviewCancers2024

An Overview for Clinicians on Intraductal Papillary Mucinous Neoplasms (IPMNs) of the Pancreas.

Dimitrios Moris, Ioannis Liapis, Piyush Gupta, Ioannis A Ziogas, Georgia-Sofia Karachaliou, Nikolaos Dimitrokallis, Brian Nguyen, Pejman Radkani

Abstract readReview
In one paragraph

Review in Cancers, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Dimitrios MorisMedStar Georgetown Transplant Institute, Washington, DC 20007, USA.ORCID 0000-0002-5276-0699
Ioannis LiapisDepartment of Surgery, University of Alabama at Birmingham, Birmingham, AL 35294, USA.ORCID 0000-0001-6240-4228
Piyush GuptaMedStar Georgetown Transplant Institute, Washington, DC 20007, USA.
Ioannis A ZiogasDepartment of Surgery, University of Colorado School of Medicine, Aurora, CO 80045, USA.ORCID 0000-0002-6742-6909
Georgia-Sofia KarachaliouDivision of Gastroenterology, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA.
Nikolaos Dimitrokallis1st Department of Surgery & Organ Transplant Unit, Evangelismos General Hospital, 10676 Athens, Greece.ORCID 0000-0002-0757-3712
Brian NguyenMedStar Georgetown Transplant Institute, Washington, DC 20007, USA.
Pejman RadkaniMedStar Georgetown Transplant Institute, Washington, DC 20007, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Currently, there is no reliable method of discerning between low-risk and high-risk intraductal papillary mucinous neoplasms (IPMNs). Operative resection is utilized in an effort to resect those lesions with high-grade dysplasia (HGD) prior to the development of invasive disease. The current guidelines recommend resection for IPMN that involve the main pancreatic duct. Resecting lesions with HGD before their progression to invasive disease and the avoidance of resection in those patients with low-grade dysplasia is the optimal clinical scenario. Therefore, the importance of developing preoperative models able to discern HGD in IPMN patients cannot be overstated. Low-risk patients should be managed with nonsurgical treatment options (typically MRI surveillance), while high-risk patients would undergo resection, hopefully prior to the formation of invasive disease. Current research is evolving in multiple directions. First, there is an ongoing effort to identify reliable markers for predicting malignant transformation of IPMN, mainly focusing on genomic and transcriptomic data from blood, tissue, and cystic fluid. Also, multimodal models of combining biomarkers with clinical and radiographic data seem promising for providing robust and accurate answers of risk levels for IPMN patients.

Indexed as

biomarkersintraductal papillary mucinous neoplasmspancreatic cancers

Identifiers

PMID39594780
PMCPMC11593033

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.