Evidence map›Paper›PMID 39594720›Full record

ArticleCancers2024

Tumor-Infiltrating B Cells and Tissue-Resident Memory T Cells as Prognostic Indicators in Brain Metastases Derived from Gastrointestinal Cancers.

Masasuke Ohno, Shunichiro Kuramitsu, Kimihiro Yamashita, Toru Nagasaka, Shoichi Haimoto, Mitsugu Fujita

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Masasuke OhnoDepartment of Neurosurgery, Aichi Cancer Center, Nagoya 464-8681, Japan.
Shunichiro KuramitsuDepartment of Neurosurgery, Nagoya Medical Center, Nagoya 460-0001, Japan.
Kimihiro YamashitaDivision of Gastrointestinal Surgery, Department of Surgery, Graduate School of Medicine, Kobe University, Kobe 650-0017, Japan.ORCID 0000-0002-4208-7138
Toru NagasakaDivision of Gastrointestinal Surgery, Department of Surgery, Graduate School of Medicine, Kobe University, Kobe 650-0017, Japan.
Shoichi HaimotoDepartment of Neurosurgery, Aichi Cancer Center, Nagoya 464-8681, Japan.
Mitsugu FujitaDivision of Gastrointestinal Surgery, Department of Surgery, Graduate School of Medicine, Kobe University, Kobe 650-0017, Japan.ORCID 0000-0002-0000-9879

Funding

Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology of Japan 22K09223, 23K15677, 23K08171, 21K09167
6 · The paper itself

Abstract

BACKGROUND/

objectivesTumor-infiltrating B cells (TIBs) and tissue-resident memory T cells (TRMs) play significant roles in antitumor immunity. However, their prognostic relevance in brain metastases (BMs) derived from gastrointestinal (GI) cancers remains unclear. This study aimed to investigate the prognostic significance of TIBs and TRMs in GI cancer-derived BMs (GIBMs).

methodsRetrospective histopathological analyses were performed on surgically resected GIBM tissues from 13 patients. The densities of tumor-infiltrating lymphocytes (TIL) subsets (TIBs, CD4

resultsTIBs and CD4

conclusionsTIB and TRM densities in BM tissues could serve as reliable prognostic indicators for survival in patients with GIBMs. This study provides crucial insights for the development of novel immunotherapeutic strategies against this lethal disease.

Indexed as

brain metastasesgastrointestinal cancersprognostic indicatorstertiary lymphoid structurestissue-resident memory T cellstumor immune microenvironmenttumor-infiltrating B cells

Identifiers

PMID39594720
PMCPMC11591993

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.