Evidence map›Paper›PMID 39594712›Full record

ArticleCancers2024

Perioperative Observations and Outcome in Surgical Treatment of Malignant Peripheral Nerve Sheath Tumors.

Julian Zipfel, Jonas Tellermann, Kevin Paul Ferraris, Florian Grimm, Antje Bornemann, Benjamin Bender, Helmut Dittmann, Jürgen Schäfer, Konstantin Nikolaou, Ruth Ladurner and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Julian ZipfelDepartment of Neurosurgery, University Hospital Tübingen, BW 72076 Tübingen, Germany.
Jonas TellermannDepartment of Neurosurgery, University Hospital Tübingen, BW 72076 Tübingen, Germany.
Kevin Paul FerrarisDivision of Pediatric Neurosurgery, BC Children's Hospital, University of British Columbia, Vancouver, BC V6H 3N1, Canada.ORCID 0000-0002-0919-6658
Florian GrimmDepartment of Neurosurgery, University Hospital Tübingen, BW 72076 Tübingen, Germany.
Antje BornemannDepartment of Pathology and Neuropathology and Comprehensive Cancer Center, University Hospital Tübingen, BW 72076 Tübingen, Germany.
Benjamin BenderDepartment of Diagnostic and Interventional Neuroradiology, University Hospital Tübingen, BW 72076 Tübingen, Germany.ORCID 0000-0002-3205-4631
Helmut DittmannDepartment of Nuclear Medicine and Clinical Molecular Imaging, University Hospital Tübingen, BW 72076 Tübingen, Germany.
Jürgen SchäferDepartment of Diagnostic and Interventional Radiology, University Hospital Tübingen, BW 72076 Tübingen, Germany.
Konstantin NikolaouDepartment of Diagnostic and Interventional Radiology, University Hospital Tübingen, BW 72076 Tübingen, Germany.
Ruth LadurnerDepartment of General, Visceral and Transplantation Surgery, University Hospital Tübingen, BW 72076 Tübingen, Germany.
Volker StegerDepartment of Thoracic and Cardiovascular Surgery, German Cardiac Competence Center, University Hospital Tübingen, BW 72076 Tübingen, Germany.
Marcos TatagibaDepartment of Neurosurgery, University Hospital Tübingen, BW 72076 Tübingen, Germany.
Martin U SchuhmannDepartment of Neurosurgery, University Hospital Tübingen, BW 72076 Tübingen, Germany.
Isabel GugelDepartment of Neurosurgery, University Hospital Tübingen, BW 72076 Tübingen, Germany.

Funding

Ministerium für Wissenschaft, Forschung und Kultur 31-7635.41/215/2
6 · The paper itself

Abstract

BACKGROUND/

objectivesThis retrospective observational study aimed to investigate the perioperative outcome in Malignant Peripheral Nerve Sheath Tumors (MPNSTs) with and without relation to Neurofibromatosis Type 1 (NF1) and to detect possible influencing factors.

methodsClinical reports, histopathological evaluations, imaging, and treatment characteristics were reviewed in 35 operated MPNSTs in 33 patients. Possible predictive valuables included disease type, preoperative tumor volume, SUV and MIB-1 proliferation index, resection margins, the presence of metastasis, and whether radio-/chemotherapy was received.

resultsPatients with NF1 were younger (mean age: 29 ± 13, 8-54 years) than sporadic cases (mean age: 45 ± 13, 24-67 years) and exhibited significantly larger preoperative tumor volumes (mean 299 vs. 18 cm

conclusionsNF1-associated MPNSTs have larger tumor volumes, higher SUVs and MIB-1 proliferation indices, and a shorter overall survival period. Nevertheless, surgery can improve symptoms, particularly medication-resistant pain, and should also be considered in advanced disease for symptom control/improvement.

Indexed as

FDG-PETmalignant peripheral nerve sheath tumorMIB-1neurofibromaneurofibromatosis type 1surgery

Identifiers

PMID39594712
PMCPMC11592335

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.