Dynamic Contrast-Enhanced and Diffusion-Weighted Imaging in Magnetic Resonance in the Assessment of Peritoneal Recurrence of Ovarian Cancer in Patients with or Without BRCA Mutation.

Melania Jankowska-Lombarska, Laretta Grabowska-Derlatka, Leszek Kraj, Pawel Derlatka

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Article in Cancers, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 authors.

Melania Jankowska-LombarskaSecond Department of Radiology, Medical University of Warsaw, Banacha 1a St., 02-097 Warsaw, Poland.

Laretta Grabowska-DerlatkaSecond Department of Radiology, Medical University of Warsaw, Banacha 1a St., 02-097 Warsaw, Poland.ORCID 0000-0002-6511-6579

Leszek KrajDepartment of Oncology, Medical University of Warsaw, Banacha 1a St., 02-097 Warsaw, Poland.

Pawel DerlatkaSecond Department of Obstetrics and Gynecology, Medical University of Warsaw, Karowa 2 St., 00-315 Warsaw, Poland.ORCID 0000-0001-9406-6868

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6 · The paper itself

Abstract

backgroundThe aim of this study was to determine the differences in diffusion-weighted imaging (DWI) and dynamic contrast enhancement (DCE) parameters between patients with peritoneal high-grade serous ovarian cancer (HGSOC) recurrence with BRCA mutations (BRCAmut) or BRCA wild type (BRCAwt). MATERIALS AND

methodsWe retrospectively analyzed the abdominal and pelvic magnetic resonance (MR) images of 43 patients suspected of having recurrent HGSOC, of whom 18 had BRCA1/2 gene mutations. Patients underwent MRI examination via a 1.5 T MRI scanner, and the analyzed parameters were as follows: apparent diffusion coefficient (ADC), time to peak (TTP) and perfusion maximum enhancement (Perf. Max. En.).

resultsThe mean ADC in patients with BRCAwt was lower than that in patients with BRCAmut: 788.7 (

conclusionOur study revealed a statistically significant correlation between DWI and DCE parameters in examinations of peritoneal metastasis in patients with BRCA1/2 mutations. Adding DCE perfusion to the MRI protocol for ovarian cancer recurrence in patients with BRCAmut may be a valuable tool.

Indexed as

BRCA 1 or BRCA2 mutationsDCEDWIMRIovarian cancerrecurrence

Identifiers

PMID39594694

DOI10.3390/cancers16223738

PMCPMC11591656

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