Evidence map›Paper›PMID 39594632›Full record

ArticleCells2024

Circulating Micro-RNAs Predict the Risk of Recurrence in Triple-Negative Breast Cancer.

Jouni Kujala, Maria Tengström, Sami Heikkinen, Mari Taipale, Veli-Matti Kosma, Jaana M Hartikainen, Arto Mannermaa

Abstract read
In one paragraph

Article in Cells, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. Review
  6. Article
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  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jouni KujalaInstitute of Clinical Medicine, Clinical Pathology and Forensic Medicine, University of Eastern Finland, FI-70211 Kuopio, Finland.ORCID 0000-0002-7221-5938
Maria TengströmCancer Center, Department of Oncology, Kuopio University Hospital, FI-70029 Kuopio, Finland.
Sami HeikkinenInstitute of Biomedicine, School of Medicine, University of Eastern Finland, FI-70211 Kuopio, Finland.
Mari TaipaleInstitute of Biomedicine, School of Medicine, University of Eastern Finland, FI-70211 Kuopio, Finland.
Veli-Matti KosmaInstitute of Clinical Medicine, Clinical Pathology and Forensic Medicine, University of Eastern Finland, FI-70211 Kuopio, Finland.
Jaana M HartikainenInstitute of Clinical Medicine, Clinical Pathology and Forensic Medicine, University of Eastern Finland, FI-70211 Kuopio, Finland.
Arto MannermaaInstitute of Clinical Medicine, Clinical Pathology and Forensic Medicine, University of Eastern Finland, FI-70211 Kuopio, Finland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer with a high tendency for developing a recurrent disease. Circulating micro-RNAs (cmiRNAs) obtained through liquid biopsy are potential prognostic biomarkers for the assessment of TNBC recurrence risk. In this study, we sequenced cmiRNAs from the serum samples of 14 recurrent and 19 non-recurrent TNBC cases and compared expression profiles in relation to recurrence status, survival data and miRNA expression in matched tumor samples. Differential expression analysis between recurrent and non-recurrent cases identified ten differentially expressed (DE) cmiRNAs, of which cmiRNAs miR-21-5p (

Indexed as

Circulating MicroRNANeoplasm Recurrence, LocalTriple Negative Breast NeoplasmsAdultAgedBiomarkers, TumorFemaleGene Expression Regulation, NeoplasticHumansMicroRNAsMiddle AgedPrognosisRisk FactorsBiomarkers, TumorCirculating MicroRNAMicroRNAsliquid biopsysequencingserumsurvival

Identifiers

PMID39594632
PMCPMC11593277

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.