Evidence map›Paper›PMID 39594630›Full record

ArticleCells2024

Non-Immune-Mediated, p27-Associated, Growth Inhibition of Glioblastoma by Class-II-Transactivator (CIITA).

A Katherine Tan, Aurelie Henry, Nicolas Goffart, Christophe Poulet, Jacqueline A Sluijs, Elly M Hol, Vincent Bours, Pierre A Robe

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

A Katherine TanDepartment of Translational Neuroscience, University Medical Center Utrecht (UMCU) Brain Center, Utrecht University, 3584 CX Utrecht, The Netherlands.
Aurelie HenryDepartment of Human Genetics, University of Liège, 4000 Liège, Belgium.
Nicolas GoffartDepartment of Human Genetics, University of Liège, 4000 Liège, Belgium.
Christophe PouletDepartment of Human Genetics, University of Liège, 4000 Liège, Belgium.ORCID 0000-0003-4055-5441
Jacqueline A SluijsDepartment of Translational Neuroscience, University Medical Center Utrecht (UMCU) Brain Center, Utrecht University, 3584 CX Utrecht, The Netherlands.
Elly M HolDepartment of Translational Neuroscience, University Medical Center Utrecht (UMCU) Brain Center, Utrecht University, 3584 CX Utrecht, The Netherlands.ORCID 0000-0001-5604-2603
Vincent BoursDepartment of Human Genetics, University of Liège, 4000 Liège, Belgium.
Pierre A RobeDepartment of Translational Neuroscience, University Medical Center Utrecht (UMCU) Brain Center, Utrecht University, 3584 CX Utrecht, The Netherlands.ORCID 0000-0001-7845-6196

Funding

Fonds de la Recherche Scientifique of Belgium grants 8.4628.16, 7.4639.17
6 · The paper itself

Abstract

backgroundPrevious works have shown that the expression of Class-II-Transactivator (CIITA) in tumor cells reduces the growth of glioblastoma (GB) in animal models, but immune effects cannot solely explain this. Here, we searched for immune-independent effects of CIITA on the proliferation of GB.

methodsMurine GL261 and human U87, GM2 and GM3 malignant glioma cells were transfected with CIITA. NSG (immunodeficient) and nude (athymic) mice were injected in the striatum with GL261-wildtype (-WT) and -CIITA, and tumor growth was assessed by immunohistology and luminescence reporter genes. Clonogenic, sphere-formation, and 3D Matrigel-based in vitro growth assays were performed to compare the growth of WT versus CIITA-expressing murine and human cells. Bulk RNA sequencing and RT

resultsThe intracerebral growth of murine GL261-CIITA cells was drastically reduced both in immunodeficient and athymic mice. Tumor growth was reduced in vitro in three of the four cell types. RNA sequencing and RT

conclusionsProliferation is drastically reduced by CIITA in GB, both in vivo and in vitro, notably in association with p27-mediated inhibition of cell-cycle pathways.

Indexed as

Cell ProliferationGlioblastomaNuclear ProteinsTrans-ActivatorsAnimalsBrain NeoplasmsCell Line, TumorCyclin-Dependent Kinase Inhibitor p27Gene Expression Regulation, NeoplasticHumansMiceMice, NudeCyclin-Dependent Kinase Inhibitor p27MHC class II transactivator proteinNuclear ProteinsTrans-ActivatorsClass-II-TransactivatorglioblastomaPI3-AktproliferationSTAT3

Identifiers

PMID39594630
PMCPMC11593141

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.