Evidence map›Paper›PMID 39594581›Full record

ArticleCells2024

An Investigation of RNA Methylations with Biophysical Approaches in a Cervical Cancer Cell Model.

Buket Sağlam, Onur Akkuş, Azime Akçaöz-Alasar, Çağatay Ceylan, Günnur Güler, Bünyamin Akgül

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. mPharmaceuticals (Basel, Switzerland) · 2026
    Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Buket SağlamNoncoding RNA Laboratory, Department of Molecular Biology and Genetics, İzmir Institute of Technology, 35430 Izmir, Türkiye.ORCID 0009-0000-9991-3042
Onur AkkuşBiophysics Laboratory, Department of Physics, İzmir Institute of Technology, 35430 Izmir, Türkiye.
Azime Akçaöz-AlasarNoncoding RNA Laboratory, Department of Molecular Biology and Genetics, İzmir Institute of Technology, 35430 Izmir, Türkiye.ORCID 0000-0002-5338-527X
Çağatay CeylanDepartment of Food Engineering, İzmir Institute of Technology, 35430 Izmir, Türkiye.
Günnur GülerBiophysics Laboratory, Department of Physics, İzmir Institute of Technology, 35430 Izmir, Türkiye.ORCID 0000-0002-8485-7372
Bünyamin AkgülNoncoding RNA Laboratory, Department of Molecular Biology and Genetics, İzmir Institute of Technology, 35430 Izmir, Türkiye.ORCID 0000-0001-9877-9689

Funding

Scientific Research Projects of Izmir Institute of Technology 2022IYTE_2_0048
6 · The paper itself

Abstract

RNA methylation adds a second layer of genetic information that dictates the post-transcriptional fate of RNAs. Although various methods exist that enable the analysis of RNA methylation in a site-specific or transcriptome-wide manner, whether biophysical approaches can be employed to such analyses is unexplored. In this study, Fourier-transform infrared (FT-IR) and circular dichroism (CD) spectroscopy are employed to examine the methylation status of both synthetic and cellular RNAs. The results show that FT-IR spectroscopy is perfectly capable of quantitatively distinguishing synthetic m

Indexed as

RNAUterine Cervical NeoplasmsBiophysical PhenomenaCircular DichroismFemaleHeLa CellsHumansMethylationMethyltransferasesRNA MethylationSpectroscopy, Fourier Transform InfraredTumor Necrosis Factor-alphaMethyltransferasesMETTL3 protein, humanRNATumor Necrosis Factor-alphaapoptosiscircular dichroismFT-IRm6AN6-methyladenosineTNF-α

Identifiers

PMID39594581
PMCPMC11592517

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.