Evidence map›Paper›PMID 39594567›Full record

ArticleAntioxidants (Basel, Switzerland)2024

25-Hydroxycholecalciferol Improves Cardiac Metabolic Adaption, Mitochondrial Biogenetics, and Redox Status to Ameliorate Pathological Remodeling and Functional Failure in Obese Chickens.

Shih-Kai Chiang, Mei-Ying Sin, Jun-Wen Lin, Maraddin Siregar, Gilmour Valdez, Yu-Hui Chen, Thau Kiong Chung, Rosemary L Walzem, Lin-Chu Chang, Shuen-Ei Chen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Redox Homeostasis in Poultry/Animal Production.Antioxidants (Basel, Switzerland) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Shih-Kai ChiangDepartment of Animal Science, National Chung Hsing University, Taichung 40227, Taiwan.
Mei-Ying SinChinese Medicinal Research and Development Center, China Medical University Hospital, Taichung 40447, Taiwan.ORCID 0009-0007-6261-5050
Jun-Wen LinDepartment of Animal Science, National Chung Hsing University, Taichung 40227, Taiwan.
Maraddin SiregarDepartment of Animal Science, National Chung Hsing University, Taichung 40227, Taiwan.
Gilmour ValdezDepartment of Animal Science, National Chung Hsing University, Taichung 40227, Taiwan.
Yu-Hui ChenDepartment of Animal Science, National Chung Hsing University, Taichung 40227, Taiwan.
Thau Kiong ChungDSM Nutritional Products Asia Pacific, Mapletree Business City, Singapore 117440, Singapore.
Rosemary L WalzemDepartment of Poultry Science, Texas A&M University, College Station, TX 77843, USA.ORCID 0000-0002-9913-7810
Lin-Chu ChangChinese Medicinal Research and Development Center, China Medical University Hospital, Taichung 40447, Taiwan.
Shuen-Ei ChenDepartment of Animal Science, National Chung Hsing University, Taichung 40227, Taiwan.ORCID 0000-0003-1737-2591

Funding

DSM Nutritional Products Asia Pacific, Singapore The grant to S.E. Chenthe Ministry of Education, Taiwan Cancer Biology and Precision Therapeutics Center, China Medical University, through The Featured Areas Research Center Program within the framework of the Higher Education Sprout Projectthe Ministry of Education, Taiwan the iEGG and Animal Biotechnology Center and the Innovation and Development Center of Sustainable Agriculture from The Featured Areas Research Center Program within the frame-work of the Higher Education Sprout Project (MOE-113-S-0023-A)the Ministry of Science and Technology, Taiwan NSTC-113-2313-B-005-041-MY2, NSTC 113-2321-B-005-008,NSTC 110-2320-B-039-013-MY3, NSTC 113-2320-B-039-065United States Department of Agriculture Texas AgriLife Research project number 8738
6 · The paper itself

Abstract

Broiler breeder hens allowed ad libitum (Ad) feed intake developed obesity and cardiac pathogenesis and thereby were susceptible to sudden death. A supplement of 69 µg 25-hydroxycholecalciferol (25-OH-D3)/kg feed rescued the livability of feed-restricted (R) and Ad-hens (mortality; 6.7% vs. 8.9% and 31.1% vs. 48.9%). Necropsy with the surviving counterparts along the time course confirmed alleviation of myocardial remodeling and functional failure by 25-OH-D3, as shown by BNP and MHC-β expressions, pathological hypertrophy, and cardiorespiratory responses (

Indexed as

heart failurehensmetabolic adaptionmitochondriaredox homeostasisvitamin D

Identifiers

PMID39594567
PMCPMC11590958

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.