Evidence map›Paper›PMID 39594503›Full record

ArticleAntioxidants (Basel, Switzerland)2024

SOD1 Is an Integral Yet Insufficient Oxidizer of Hydrogen Sulfide in Trisomy 21 B Lymphocytes and Can Be Augmented by a Pleiotropic Carbon Nanozyme.

Karthik Mouli, Anton V Liopo, Larry J Suva, Kenneth R Olson, Emily A McHugh, James M Tour, Paul J Derry, Thomas A Kent

Abstract read
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Research square · 2026
    Article
  3. Article
  4. Role of cystathionine-β-synthase and hydrogen sulfide in down syndrome.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025
    Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Karthik MouliCenter for Genomics and Precision Medicine, Institute of Bioscience and Technology, Texas A&M University Health Science Center, Houston, TX 77030, USA.ORCID 0000-0002-1671-5727
Anton V LiopoCenter for Genomics and Precision Medicine, Institute of Bioscience and Technology, Texas A&M University Health Science Center, Houston, TX 77030, USA.ORCID 0000-0003-4218-2159
Larry J SuvaDepartment of Veterinary Physiology and Pharmacology, School of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX 77843, USA.ORCID 0000-0002-2892-9757
Kenneth R OlsonDepartment of Physiology, Indiana University School of Medicine South Bend, South Bend, IN 46617, USA.ORCID 0000-0003-0178-2203
Emily A McHughDepartment of Chemistry, Rice University, Houston, TX 77005, USA.
James M TourDepartment of Chemistry, Rice University, Houston, TX 77005, USA.
Paul J DerryCenter for Genomics and Precision Medicine, Institute of Bioscience and Technology, Texas A&M University Health Science Center, Houston, TX 77030, USA.
Thomas A KentCenter for Genomics and Precision Medicine, Institute of Bioscience and Technology, Texas A&M University Health Science Center, Houston, TX 77030, USA.ORCID 0000-0002-9877-7584

Funding

Novel Carbon Nanozyme Mechanisms for Traumatic Brain InjuryR01NS094535 · NINDS · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI HEGDE, MURALIDHAR L, KENT, THOMAS · 2015 to 2024
$4.1M
Understanding the skeleton in Down SyndromeR01HD102909 · NICHD · TEXAS A&M AGRILIFE RESEARCH · PI SUVA, LARRY J. · 2021 to 2025
$2.8M
NICHD NIH HHS R01 HD102909NIH HHS 5R01NS094535-09A1NINDS NIH HHS R01 NS094535Welch Foundation BE-0048
6 · The paper itself

Abstract

Down syndrome (DS) is a multisystemic disorder that includes accelerated aging caused by trisomy 21. In particular, overexpression of cystathionine-β-synthase (CBS) is linked to excess intracellular hydrogen sulfide (H

Indexed as

Down syndromenanozymeoxidative stresssulfide

Identifiers

PMID39594503
PMCPMC11591310

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.