Evidence map›Paper›PMID 39594485›Full record

ReviewAntioxidants (Basel, Switzerland)2024

Mitochondrial Quality Control in Alzheimer's Disease: Insights from

Upasana Ganguly, Trae Carroll, Keith Nehrke, Gail V W Johnson

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Antioxidants (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Upasana GangulyDepartment of Anesthesiology and Perioperative Medicine, University of Rochester Medical Center (URMC), Rochester, NY 14642, USA.
Trae CarrollDepartment of Pathology, University of Rochester Medical Center (URMC), Rochester, NY 14642, USA.ORCID 0000-0001-5648-2772
Keith NehrkeDepartment of Medicine, Nephrology Division, University of Rochester Medical Center (URMC), Rochester, NY 14642, USA.ORCID 0000-0001-9697-726X
Gail V W JohnsonDepartment of Anesthesiology and Perioperative Medicine, University of Rochester Medical Center (URMC), Rochester, NY 14642, USA.ORCID 0000-0003-3464-0404

Funding

Tau Post-Translational Modifications and Mitochondrial Quality ControlR01AG067617 · NIA · UNIVERSITY OF ROCHESTER · PI JOHNSON, GAIL V. W., NEHRKE, KEITH · 2020 to 2024
$2.9M
NIH HHS R01AG067617
6 · The paper itself

Abstract

Alzheimer's disease (AD) is a complex neurodegenerative disorder that is classically defined by the extracellular deposition of senile plaques rich in amyloid-beta (Aβ) protein and the intracellular accumulation of neurofibrillary tangles (NFTs) that are rich in aberrantly modified tau protein. In addition to aggregative and proteostatic abnormalities, neurons affected by AD also frequently possess dysfunctional mitochondria and disrupted mitochondrial maintenance, such as the inability to eliminate damaged mitochondria via mitophagy. Decades have been spent interrogating the etiopathogenesis of AD, and contributions from model organism research have aided in developing a more fundamental understanding of molecular dysfunction caused by Aβ and toxic tau aggregates. The soil nematode

Indexed as

agingAlzheimer’s diseaseCaenorhabditis elegansmitochondriamitochondria quality controlmitophagymodel organismneurodegeneration

Identifiers

PMID39594485
PMCPMC11590956

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.