Evidence map›Paper›PMID 39594475›Full record

ArticleAntioxidants (Basel, Switzerland)2024

Role of Paraoxonase 2 in Airway Epithelial Response to Oxidant Stress.

Matthew S McCravy, Zhonghui Yang, Jaime Cyphert-Daly, Zachary R Healy, Aaron V Vose, Haein R Kim, Julia K L Walker, Robert M Tighe, Heath G Gasier, Jennifer L Ingram and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Matthew S McCravyDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Duke University, Durham, NC 27710, USA.ORCID 0000-0001-5313-211X
Zhonghui YangDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Duke University, Durham, NC 27710, USA.
Jaime Cyphert-DalyDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Duke University, Durham, NC 27710, USA.
Zachary R HealyDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Duke University, Durham, NC 27710, USA.
Aaron V VoseDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Duke University, Durham, NC 27710, USA.ORCID 0000-0003-2745-7070
Haein R KimDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Duke University, Durham, NC 27710, USA.
Julia K L WalkerSchool of Nursing, Duke University, Durham, NC 27710, USA.
Robert M TigheDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Duke University, Durham, NC 27710, USA.ORCID 0000-0002-3465-9861
Heath G GasierDepartment of Anesthesiology, Duke University, Durham, NC 27710, USA.ORCID 0000-0001-5895-4542
Jennifer L IngramDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Duke University, Durham, NC 27710, USA.ORCID 0000-0002-5269-8864
Loretta G QueDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Duke University, Durham, NC 27710, USA.ORCID 0000-0001-9188-9244

Funding

SANDIA: Supplementing L-citrulline to overweight late Asthma oNset phenotypes to increase airway L-arginine/ADMA ratio and Improve Asthma controlR01HL146542 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI HOLGUIN, FERNANDO, QUE, LORETTA G · 2019 to 2023
$3.6M
Oxidative Stress and Regional Airway Remodeling and Fibrosis in Obese AsthmaR01HL153641 · NHLBI · DUKE UNIVERSITY · PI QUE, LORETTA G · 2020 to 2023
$3.0M
The Role of PON2 in the Development of Non-Allergic Asthma in ObesityF32HL165697 · NHLBI · DUKE UNIVERSITY · PI MCCRAVY, MATTHEW · 2022 to 2023
$150k
NHLBI NIH HHS 1-F32HL-165697NHLBI NIH HHS F32 HL165697NHLBI NIH HHS R01 HL146542NHLBI NIH HHS R01 HL153641
6 · The paper itself

Abstract

Asthma is a widespread chronic lung disease characterized by airway inflammation and hyperresponsiveness. This airway inflammation is classified by either the presence (T2-high) or absence (T2-low) of high levels of eosinophils. Because most therapies for asthma target eosinophils and related pathways, treatment options for T2-low disease are limited. New pathophysiologic targets are needed. Oxidant stress is a common feature of T2-low disease. Airway epithelial expression of the antioxidant enzyme Paraoxonase 2 (PON2) is decreased in a well-recognized population of people with T2-low asthma and people with obesity and asthma. As a potential mechanism of increased oxidant stress, we measured the role of PON2 in lung oxidant responses using an environmentally relevant in vivo murine oxidant exposure (i.e., ozone) and in vitro studies with an immortalized human airway epithelial cell line BEAS-2B. Pon2-deficient (

Indexed as

asthmamitochondriaoxidant stressozoneparaoxonase

Identifiers

PMID39594475
PMCPMC11591210

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.