Evidence map›Paper›PMID 39594446›Full record

ReviewAntioxidants (Basel, Switzerland)2024

Apnea of Prematurity and Oxidative Stress: Potential Implications.

Lauren Thompson, Joseph W Werthammer, David Gozal

Registry-linked trialAbstract readReview
In one paragraph

Review in Antioxidants (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07324941 (The Role of Electroencephalography Evaluation in Caffeine Discontinuation Timing in Premature Infants), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07324941 recruitingnot on this mapstarted 2026, after this paper: background citation

The Role of Electroencephalography Evaluation in Caffeine Discontinuation Timing in Premature Infants

Typeobservational_patient_registrySponsorUludag UniversityRan2026 to 2027Enrolled100ConditionsApnea Neonatal, Apnea of Prematurity
3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Lauren ThompsonDepartment of Pediatrics, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV 25701, USA.
Joseph W WerthammerDepartment of Pediatrics, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV 25701, USA.
David GozalDepartment of Pediatrics, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV 25701, USA.ORCID 0000-0001-8195-6036

Funding

Coronary artery dysfunction in OSA: Role of mineralocorticoid receptorsR01HL166617 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI Mohammad Badran · 2023 to 2026
$2.5M
p16 Cellular Senescence and Vascular Dysfunction in Sleep ApneaR01HL169266 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI Rene Gabriel Cortese · 2024 to 2026
$2.2M
NHLBI NIH HHS R01 HL166617NHLBI NIH HHS R01 HL169266
6 · The paper itself

Abstract

Apnea of prematurity (AOP) occurs in 85% of neonates ≤34 weeks of gestational age. AOP is frequently associated with intermittent hypoxia (IH). This narrative review reports on the putative relationship of AOP with IH and the resulting oxidative stress (OS). Preterm infants are susceptible to OS due to an imbalance between oxidant and antioxidant systems with the excessive free radical load leading to serious morbidities that may include retinopathy of prematurity, bronchopulmonary dysplasia, and neurodevelopmental delay. Current therapeutic approaches to minimize the adverse effects of AOP and optimize oxygen delivery include noninvasive ventilation and xanthine inhibitor therapy, but these approaches have only been partially successful in decreasing the incidence of AOP and associated morbidities.

Indexed as

apnea of prematuritybronchopulmonary dysplasiacognitive developmentCPAPintermittent hypoxianecrotizing enterocolitisoxidative stressretinopathy of prematuritysupplemental oxygen

Identifiers

PMID39594446
PMCPMC11591010

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.