ArticleDiagnostics (Basel, Switzerland)2024
Reduction in Synovitis Following Genicular Artery Embolization in Knee Osteoarthritis: A Prospective Ultrasound and MRI Study.
Article in Diagnostics (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Outcome and Safety of Genicular Artery Embolization for Knee Osteoarthritis: A Systematic Review and Meta-Analysis.Cardiovascular and interventional radiology · 2026Pooled it
- Genicular Artery Embolization for Chronic Exudative Knee Synovitis: Prospective 6-Month Clinical and Functional Outcomes.Journal of clinical medicine · 2026Article
- Genicular Artery Embolization as a Treatment Option for Refractory Knee Pain Post Total Knee Arthroplasty: A Prospective Series.Cardiovascular and interventional radiology · 2026Article
- Multimodality imaging considerations for genicular artery embolization in knee osteoarthritis.World journal of radiology · 2026Review
- Genicular artery embolization for treating knee osteoarthritis - an overview of the evidence.Pain management · 2026Review
- Genicular Arteries Embolization for Patients with Osteoarthritis, Their Selection, and Follow-Up Based on MRI Findings.Medicina (Kaunas, Lithuania) · 2025Review
- Genicular Artery Embolization: A Technical Review of Anatomy, Pathophysiology, Current Experiences, and Future Directions.Journal of clinical medicine · 2025Review
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
BACKGROUND/
objectivesGenicular artery embolization (GAE) has demonstrated potential as a treatment for knee osteoarthritis by targeting inflammation and pain, although current evidence remains limited. This study used imaging biomarkers to objectively assess synovitis and possible ischemic complications following GAE.
methodsThis was a prospective, single-center trial including participants with mild-to-moderate knee osteoarthritis. Ultrasound, contrast-enhanced (CE), and non-CE-MRI were performed two days before and one and six months after GAE. Ultrasound biomarkers included synovial hypertrophy, effusion, and Doppler activity. A combined effusion-synovitis score was assessed on non-CE-MRI, while CE-MRI allowed differentiation between synovium and effusion and was used to calculate whole-joint and local synovitis scores. The post-GAE MRIs were reviewed for ischemic complications.
resultsSeventeen participants (aged 43-71) were treated. Significant reductions were observed in ultrasound-assessed synovial hypertrophy and Doppler activity, as well as in CE-MRI local and whole-joint synovitis scores. While reductions in effusion were noted in both ultrasound and MRI, these changes did not reach statistical significance. At one month, MRI revealed three cases of nonspecific osteonecrosis-like areas, which resolved completely by six months.
conclusionsThis study demonstrated a reduction in synovitis and no permanent ischemic complication following GAE in knee osteoarthritis. Larger studies with longer follow-up are needed to confirm the long-term efficacy and safety of the procedure.
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