Evidence map›Paper›PMID 39594133›Full record

ArticleDiagnostics (Basel, Switzerland)2024

A Comparative Study of Methyl-BEAMing and Droplet Digital PCR for

Marco Macagno, Valeria Pessei, Noemi Congiusta, Luca Lazzari, Sara Erika Bellomo, Fariha Idrees, Alessandro Cavaliere, Filippo Pietrantonio, Alessandra Raimondi, Eleonora Gusmaroli and 19 more

Registry-linked trialAbstract read
In one paragraph

Article in Diagnostics (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03519412 (Pembrolizumab in MMR-Proficient Metastatic Colorectal Cancer Pharmacologically Primed to Trigger Dynamic Hypermutation Status), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03519412 phase2completednot on this map

Pembrolizumab in MMR-Proficient Metastatic Colorectal Cancer Pharmacologically Primed to Trigger Dynamic Hypermutation Status

TypeinterventionalSponsorIFOM ETS - The AIRC Institute of Molecular OncologyRan2019 to 2025Enrolled107ConditionsColorectal Neoplasms, Microsatellite InstabilityArmstemozolomide (induction),, pembrolizumab (treatment)
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors.

Marco MacagnoCandiolo Cancer Institute, FPO-IRCCS, 10060 Candiolo, TO, Italy.ORCID 0000-0002-1749-7813
Valeria PesseiCandiolo Cancer Institute, FPO-IRCCS, 10060 Candiolo, TO, Italy.ORCID 0009-0004-1598-5268
Noemi CongiustaCandiolo Cancer Institute, FPO-IRCCS, 10060 Candiolo, TO, Italy.
Luca LazzariIFOM ETS-The AIRC Institute of Molecolar Oncology, 20139 Milano, MI, Italy.ORCID 0000-0001-6841-4240
Sara Erika BellomoCandiolo Cancer Institute, FPO-IRCCS, 10060 Candiolo, TO, Italy.
Fariha IdreesCandiolo Cancer Institute, FPO-IRCCS, 10060 Candiolo, TO, Italy.ORCID 0009-0007-2492-1129
Alessandro CavaliereCandiolo Cancer Institute, FPO-IRCCS, 10060 Candiolo, TO, Italy.ORCID 0000-0002-8690-5382
Filippo PietrantonioDepartment of Medical Oncology, Fondazione IRCCS, Istituto Nazionale dei Tumori, 20133 Milan, MI, Italy.ORCID 0000-0002-8530-8420
Alessandra RaimondiDepartment of Medical Oncology, Fondazione IRCCS, Istituto Nazionale dei Tumori, 20133 Milan, MI, Italy.
Eleonora GusmaroliDepartment of Medical Oncology, Fondazione IRCCS, Istituto Nazionale dei Tumori, 20133 Milan, MI, Italy.
Maria Giulia ZampinoDivision of Gastrointestinal Medical Oncology and Neuroendocrine Tumors, European Institute of Oncology, IRCCS, 20139 Milano, MI, Italy.
Lorenzo GervasoDivision of Gastrointestinal Medical Oncology and Neuroendocrine Tumors, European Institute of Oncology, IRCCS, 20139 Milano, MI, Italy.ORCID 0000-0003-3313-8527
Davide CiardielloDivision of Gastrointestinal Medical Oncology and Neuroendocrine Tumors, European Institute of Oncology, IRCCS, 20139 Milano, MI, Italy.
Giuseppe MondelloMedical Oncology and Hematology Unit, Humanitas Cancer Center, IRCCS Humanitas Research Hospital, 20089 Rozzano, MI, Italy.ORCID 0009-0004-9695-9116
Armando SantoroMedical Oncology and Hematology Unit, Humanitas Cancer Center, IRCCS Humanitas Research Hospital, 20089 Rozzano, MI, Italy.ORCID 0000-0003-1709-9492
Nicola PersoneniMedical Oncology Unit, ASST Garda, 25025 Manerbio, BS, Italy.ORCID 0000-0002-7995-272X
Emanuela BonoldiDepartment of Hematology, Oncology and Molecular Medicine, Grande Ospedale Metropolitano Niguarda, 20162 Milano, MI, Italy.ORCID 0000-0002-1047-5005
Maria Costanza AquilanoDepartment of Hematology, Oncology and Molecular Medicine, Grande Ospedale Metropolitano Niguarda, 20162 Milano, MI, Italy.ORCID 0000-0002-2955-0845
Emanuele ValtortaDepartment of Hematology, Oncology and Molecular Medicine, Grande Ospedale Metropolitano Niguarda, 20162 Milano, MI, Italy.ORCID 0000-0002-5087-6233
Salvatore SienaNiguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, 20162 Milano, MI, Italy.ORCID 0000-0002-2681-2846
Andrea Sartore-BianchiNiguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, 20162 Milano, MI, Italy.
Alessio AmatuNiguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, 20162 Milano, MI, Italy.ORCID 0000-0001-5396-3378
Erica Francesca BonazzinaNiguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, 20162 Milano, MI, Italy.
Katia Bruna BencardinoNiguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, 20162 Milano, MI, Italy.
Guido SeriniCandiolo Cancer Institute, FPO-IRCCS, 10060 Candiolo, TO, Italy.ORCID 0000-0002-3502-8367
Silvia MarsoniIFOM ETS-The AIRC Institute of Molecolar Oncology, 20139 Milano, MI, Italy.ORCID 0000-0002-5361-7122
Ludovic BaraultDepartment of Oncology, University of Torino, 10043 Orbassano, TO, Italy.ORCID 0000-0001-5227-5047
Federica Di NicolantonioCandiolo Cancer Institute, FPO-IRCCS, 10060 Candiolo, TO, Italy.ORCID 0000-0001-9618-2010
Federica MaioneCandiolo Cancer Institute, FPO-IRCCS, 10060 Candiolo, TO, Italy.

Funding

AIRC under 5 per Mille 2018 - ID. 21091 programAIRC under IG 2018- ID. 21407
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

digital PCRDNAmethylationmetastatic colorectal cancerMethyl-BEAMingMGMT

Identifiers

PMID39594133
PMCPMC11592929

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.